Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model
Alzheimer’s disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of actio...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8867547 |
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| author | Yujie Li Jing Jiang Qisheng Tang Huiling Tian Shun Wang Zidong Wang Hao Liu Jiayi Yang Jingyu Ren |
| author_facet | Yujie Li Jing Jiang Qisheng Tang Huiling Tian Shun Wang Zidong Wang Hao Liu Jiayi Yang Jingyu Ren |
| author_sort | Yujie Li |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be determined. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor that is involved in regulating neuroinflammation in AD. In this study, we applied senescence-accelerated mouse-prone 8 mice as the AD animal model, used the Morris water maze, and applied hematoxylin and eosin staining, immunofluorescence double staining, and Western blotting, to explore the effects and potential mechanisms of action of electroacupuncture. In summary, this study suggested that electroacupuncture treatment could improve the learning and memory abilities (p<0.05) and protect neurons. These effects result from acupuncture could upregulate TREM2 expression in the hippocampus (p<0.01), which was essential for the anti-inflammatory effects in the AD animal model. However, further studies are needed to conclusively demonstrate the mechanism of action of electroacupuncture in AD. |
| format | Article |
| id | doaj-art-02328f89269e44c1a070d2c2cc91f1e6 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-02328f89269e44c1a070d2c2cc91f1e62025-08-20T02:01:47ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88675478867547Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal ModelYujie Li0Jing Jiang1Qisheng Tang2Huiling Tian3Shun Wang4Zidong Wang5Hao Liu6Jiayi Yang7Jingyu Ren8Beijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaBeijing University of Chinese Medicine, Beijing, 100029, ChinaAlzheimer’s disease (AD) is one of the most serious public health concerns facing the world. Its characteristic feature is neuroinflammation due to microglial activation. Electroacupuncture is one of the therapies employed to improve the condition of patients with AD, although its mechanism of action is still to be determined. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor that is involved in regulating neuroinflammation in AD. In this study, we applied senescence-accelerated mouse-prone 8 mice as the AD animal model, used the Morris water maze, and applied hematoxylin and eosin staining, immunofluorescence double staining, and Western blotting, to explore the effects and potential mechanisms of action of electroacupuncture. In summary, this study suggested that electroacupuncture treatment could improve the learning and memory abilities (p<0.05) and protect neurons. These effects result from acupuncture could upregulate TREM2 expression in the hippocampus (p<0.01), which was essential for the anti-inflammatory effects in the AD animal model. However, further studies are needed to conclusively demonstrate the mechanism of action of electroacupuncture in AD.http://dx.doi.org/10.1155/2020/8867547 |
| spellingShingle | Yujie Li Jing Jiang Qisheng Tang Huiling Tian Shun Wang Zidong Wang Hao Liu Jiayi Yang Jingyu Ren Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model Neural Plasticity |
| title | Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model |
| title_full | Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model |
| title_fullStr | Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model |
| title_full_unstemmed | Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model |
| title_short | Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model |
| title_sort | microglia trem2 a potential role in the mechanism of action of electroacupuncture in an alzheimer s disease animal model |
| url | http://dx.doi.org/10.1155/2020/8867547 |
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