Completion of tuberculosis preventive treatment with 300 mg vs. 100 mg isoniazid tablets: a pragmatic randomized clinical trial

Completion of tuberculosis preventive treatment with 300 mg vs. 100 mg isoniazid tablets: a pragmatic randomized clinical trial

Abstract Background Monotherapy with the drug isoniazid (INH) was for a long time the main therapeutic regimen used for tuberculosis preventive treatment (TPT). Research is progressing into the use of new therapeutic regimens that provide more complete TPT. The objective was to analyze the completio...

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Main Authors: João Paulo Cola, Thiago Nascimento do Prado, Bárbara Manuella Cardoso Sodré Alves, Carolina Maia Martins Sales, Bárbara Juliana Pinheiro Borges, Keila Cristina Mascarello, Anne Caroline Barbosa Cerqueira Vieira, Silvia das Dores Rissino, Wildo Navegantes de Araújo, Noemia Urruth Leão Tavares, Ethel Leonor Noia Maciel
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Infectious Diseases
Subjects:
Latent tuberculosis
Mycobacterium tuberculosis infections
Preventive treatment of tuberculosis
Isoniazid
Pragmatic clinical trial
Online Access:https://doi.org/10.1186/s12879-025-10678-z
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