Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer
Objective：To investigate the prognostic assessment value of serum phospholipase A2(PLA2) and phosphoglycerate kinase 1(PGK1) levels in elderly patients with prostate cancer undergoing endocrine therapy. Methods： A total of 106 elderly patients with prostate cancer who underwent endocrine therapy at...
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The Editorial Department of Chinese Journal of Clinical Research
2025-02-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250218 |
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| author | CAI Chunjie, ZHANG Jin |
| author_facet | CAI Chunjie, ZHANG Jin |
| author_sort | CAI Chunjie, ZHANG Jin |
| collection | DOAJ |
| description | Objective：To investigate the prognostic assessment value of serum phospholipase A2(PLA2) and phosphoglycerate kinase 1(PGK1) levels in elderly patients with prostate cancer undergoing endocrine therapy. Methods： A total of 106 elderly patients with prostate cancer who underwent endocrine therapy at Suzhou Science and Technology City Hospital from June 2021 to June 2023 were selected as the observation group. Additionally, 60 healthy elderly individuals undergoing physical examination were set as the control group. Serum levels of PLA2 and PGK1 in all subjects were measured using enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate logistic regression analyses were used to identify factors affecting the prognosis of endocrine therapy. Results： Compared with the control group, the observation group had significantly higher serum levels of PLA2 ［(34.75±1.26)ng/mL vs (4.58±1.02)ng/mL,t=158.353,P＜0.01］ and PGK1 ［(10.69±0.36)ng/mL vs (1.54±0.07)ng/mL, t=194.561,P＜0.01］. Multivariate logistic regression analysis indicated that serum levels of PLA2, PGK1, and TNM staging of the tumor were independent prognostic factors for the efficacy of endocrine therapy in elderly patients with prostate cancer (P＜0.05). Conclusion： Serum levels of PLA2 and PGK1, along with TNM staging of the tumor, can predict the prognosis of elderly patients with prostate cancer undergoing endocrine therapy and have high predictive value.
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| format | Article |
| id | doaj-art-022a14b7e56948919bc0fdbfe2e04aa5 |
| institution | DOAJ |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-022a14b7e56948919bc0fdbfe2e04aa52025-08-20T03:11:15ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822025-02-0138225225610.13429/j.cnki.cjcr.2025.02.018Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancerCAI Chunjie, ZHANG Jin0Department of Urology, The Affiliated Suzhou Hospital of Nanjing University Medicine School, Suzhou Science and Technology City Hospital, Suzhou, Jiangsu 215153, ChinaObjective：To investigate the prognostic assessment value of serum phospholipase A2(PLA2) and phosphoglycerate kinase 1(PGK1) levels in elderly patients with prostate cancer undergoing endocrine therapy. Methods： A total of 106 elderly patients with prostate cancer who underwent endocrine therapy at Suzhou Science and Technology City Hospital from June 2021 to June 2023 were selected as the observation group. Additionally, 60 healthy elderly individuals undergoing physical examination were set as the control group. Serum levels of PLA2 and PGK1 in all subjects were measured using enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate logistic regression analyses were used to identify factors affecting the prognosis of endocrine therapy. Results： Compared with the control group, the observation group had significantly higher serum levels of PLA2 ［(34.75±1.26)ng/mL vs (4.58±1.02)ng/mL,t=158.353,P＜0.01］ and PGK1 ［(10.69±0.36)ng/mL vs (1.54±0.07)ng/mL, t=194.561,P＜0.01］. Multivariate logistic regression analysis indicated that serum levels of PLA2, PGK1, and TNM staging of the tumor were independent prognostic factors for the efficacy of endocrine therapy in elderly patients with prostate cancer (P＜0.05). Conclusion： Serum levels of PLA2 and PGK1, along with TNM staging of the tumor, can predict the prognosis of elderly patients with prostate cancer undergoing endocrine therapy and have high predictive value. http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250218prostate cancerserum phospholipase a2serum phosphoglycerate kinase 1endocrine therapytnm stageprognosis |
| spellingShingle | CAI Chunjie, ZHANG Jin Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer Zhongguo linchuang yanjiu prostate cancer serum phospholipase a2 serum phosphoglycerate kinase 1 endocrine therapy tnm stage prognosis |
| title | Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer |
| title_full | Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer |
| title_fullStr | Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer |
| title_full_unstemmed | Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer |
| title_short | Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer |
| title_sort | serum phospholipase a2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer |
| topic | prostate cancer serum phospholipase a2 serum phosphoglycerate kinase 1 endocrine therapy tnm stage prognosis |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20250218 |
| work_keys_str_mv | AT caichunjiezhangjin serumphospholipasea2andphosphoglyceratekinase1levelsforprognosticassessmentofendocrinetherapyinelderlypatientswithprostatecancer |