Current Concepts on Gastric Carcinoid Tumors

Gastric carcinoid tumors (GCs) are rare lesions representing less than 10% of carcinoid tumors and less than 1% of all stomach neoplasms. There are three distinct types of gastric carcinoids; type I includes the vast majority (70–85%) of these neoplasms that are closely linked to chronic atrophic ga...

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Main Authors: George C. Nikou, Theodoros P. Angelopoulos
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2012/287825
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author George C. Nikou
Theodoros P. Angelopoulos
author_facet George C. Nikou
Theodoros P. Angelopoulos
author_sort George C. Nikou
collection DOAJ
description Gastric carcinoid tumors (GCs) are rare lesions representing less than 10% of carcinoid tumors and less than 1% of all stomach neoplasms. There are three distinct types of gastric carcinoids; type I includes the vast majority (70–85%) of these neoplasms that are closely linked to chronic atrophic gastritis. Type II which accounts for 5–10 %, is associated with Zollinger-Ellison syndrome and often occurs in the context of multiple endocrine neoplasia type 1. Type III, finally, represents 15–25% of gastric carcinoids and is characterized by a far more aggressive course. The optimal clinical approach to GCs remains to be elucidated, depending upon type, size, and number of carcinoids. While there is universal agreement about the surgical treatment of type III GCs, current options for type I and II include simple surveillance, endoscopic polypectomy, surgical excision associated with or without surgical antrectomy, or total gastrectomy. Moreover, the introduction of somatostatin analogues could represent another therapeutic option.
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spelling doaj-art-022a083173d941d485a4b753c79f1a382025-02-03T01:07:53ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/287825287825Current Concepts on Gastric Carcinoid TumorsGeorge C. Nikou0Theodoros P. Angelopoulos1Section of Gastrointestinal Neuroendocrinology, First Department of Propaedeutic Internal Medicine, Laiko Hospital, University of Athens Medical School, Agiou Thoma 17, Goudi, 11527 Athens, GreeceSection of Gastrointestinal Neuroendocrinology, First Department of Propaedeutic Internal Medicine, Laiko Hospital, University of Athens Medical School, Agiou Thoma 17, Goudi, 11527 Athens, GreeceGastric carcinoid tumors (GCs) are rare lesions representing less than 10% of carcinoid tumors and less than 1% of all stomach neoplasms. There are three distinct types of gastric carcinoids; type I includes the vast majority (70–85%) of these neoplasms that are closely linked to chronic atrophic gastritis. Type II which accounts for 5–10 %, is associated with Zollinger-Ellison syndrome and often occurs in the context of multiple endocrine neoplasia type 1. Type III, finally, represents 15–25% of gastric carcinoids and is characterized by a far more aggressive course. The optimal clinical approach to GCs remains to be elucidated, depending upon type, size, and number of carcinoids. While there is universal agreement about the surgical treatment of type III GCs, current options for type I and II include simple surveillance, endoscopic polypectomy, surgical excision associated with or without surgical antrectomy, or total gastrectomy. Moreover, the introduction of somatostatin analogues could represent another therapeutic option.http://dx.doi.org/10.1155/2012/287825
spellingShingle George C. Nikou
Theodoros P. Angelopoulos
Current Concepts on Gastric Carcinoid Tumors
Gastroenterology Research and Practice
title Current Concepts on Gastric Carcinoid Tumors
title_full Current Concepts on Gastric Carcinoid Tumors
title_fullStr Current Concepts on Gastric Carcinoid Tumors
title_full_unstemmed Current Concepts on Gastric Carcinoid Tumors
title_short Current Concepts on Gastric Carcinoid Tumors
title_sort current concepts on gastric carcinoid tumors
url http://dx.doi.org/10.1155/2012/287825
work_keys_str_mv AT georgecnikou currentconceptsongastriccarcinoidtumors
AT theodorospangelopoulos currentconceptsongastriccarcinoidtumors