Helix Folding in One Dimension: Effects of Proline Co-Solvent on Free Energy Landscape of Hydrogen Bond Dynamics in Alanine Peptides
The effects of proline co-solvent on helix folding are explored through the single discrete coordinate of the number of helical hydrogen bonds. The analysis is based on multi-microsecond length molecular dynamics simulations of alanine-based helix-forming peptides, (ALA)n, of length n = 4, 8, 15 and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/15/5/809 |
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