Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence

The paper considers a model for the transmission dynamics of a vector-borne disease with nonlinear incidence rate. It is proved that the global dynamics of the disease are completely determined by the basic reproduction number. In order to assess the effectiveness of disease control measures, the se...

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Main Authors: Muhammad Ozair, Abid Ali Lashari, Il Hyo Jung, Kazeem Oare Okosun
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Discrete Dynamics in Nature and Society
Online Access:http://dx.doi.org/10.1155/2012/595487
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author Muhammad Ozair
Abid Ali Lashari
Il Hyo Jung
Kazeem Oare Okosun
author_facet Muhammad Ozair
Abid Ali Lashari
Il Hyo Jung
Kazeem Oare Okosun
author_sort Muhammad Ozair
collection DOAJ
description The paper considers a model for the transmission dynamics of a vector-borne disease with nonlinear incidence rate. It is proved that the global dynamics of the disease are completely determined by the basic reproduction number. In order to assess the effectiveness of disease control measures, the sensitivity analysis of the basic reproductive number R0 and the endemic proportions with respect to epidemiological and demographic parameters are provided. From the results of the sensitivity analysis, the model is modified to assess the impact of three control measures; the preventive control to minimize vector human contacts, the treatment control to the infected human, and the insecticide control to the vector. Analytically the existence of the optimal control is established by the use of an optimal control technique and numerically it is solved by an iterative method. Numerical simulations and optimal analysis of the model show that restricted and proper use of control measures might considerably decrease the number of infected humans in a viable way.
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institution Kabale University
issn 1026-0226
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publishDate 2012-01-01
publisher Wiley
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series Discrete Dynamics in Nature and Society
spelling doaj-art-021dc0e7d65049a1973787767296b41d2025-02-03T05:58:32ZengWileyDiscrete Dynamics in Nature and Society1026-02261607-887X2012-01-01201210.1155/2012/595487595487Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear IncidenceMuhammad Ozair0Abid Ali Lashari1Il Hyo Jung2Kazeem Oare Okosun3Centre for Advanced Mathematics and Physics, National University of Sciences and Technology, H-12 Campus, Islamabad 44000, PakistanCentre for Advanced Mathematics and Physics, National University of Sciences and Technology, H-12 Campus, Islamabad 44000, PakistanDepartment of Mathematics, Pusan National University, Busan 609-735, Republic of KoreaDepartment of Mathematics, Vaal University of Technology, Andries Potgieter Boulevard, Private Bag X021, Vanderbijlpark 1900, South AfricaThe paper considers a model for the transmission dynamics of a vector-borne disease with nonlinear incidence rate. It is proved that the global dynamics of the disease are completely determined by the basic reproduction number. In order to assess the effectiveness of disease control measures, the sensitivity analysis of the basic reproductive number R0 and the endemic proportions with respect to epidemiological and demographic parameters are provided. From the results of the sensitivity analysis, the model is modified to assess the impact of three control measures; the preventive control to minimize vector human contacts, the treatment control to the infected human, and the insecticide control to the vector. Analytically the existence of the optimal control is established by the use of an optimal control technique and numerically it is solved by an iterative method. Numerical simulations and optimal analysis of the model show that restricted and proper use of control measures might considerably decrease the number of infected humans in a viable way.http://dx.doi.org/10.1155/2012/595487
spellingShingle Muhammad Ozair
Abid Ali Lashari
Il Hyo Jung
Kazeem Oare Okosun
Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence
Discrete Dynamics in Nature and Society
title Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence
title_full Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence
title_fullStr Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence
title_full_unstemmed Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence
title_short Stability Analysis and Optimal Control of a Vector-Borne Disease with Nonlinear Incidence
title_sort stability analysis and optimal control of a vector borne disease with nonlinear incidence
url http://dx.doi.org/10.1155/2012/595487
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AT kazeemoareokosun stabilityanalysisandoptimalcontrolofavectorbornediseasewithnonlinearincidence