Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

Background Dickkopf 1 (DKK1) is associated with tumor progression. However, whether DKK1 influences the tumor response to programmed cell death protein 1 (PD-1) blockade in colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability (MSI) has never been clarified.Me...

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Main Authors: Yuan Li, Jian Zheng, Zhizhong Pan, Penghui Zhou, Guochen Liu, Wu Jiang, Pei-Rong Ding, Zexian Liu, Qiaoqi Sui, Dingxin Liu, Jinghua Tang, Lingheng Kong, Kai Han, Leen Liao, Qingjian Ou, Binyi Xiao, Yihong Ling, Jiewei Chen, Zhixiang Zuo
Format: Article
Language:English
Published: BMJ Publishing Group 2021-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/3/e001498.full
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