Monoclonal antibody and B-cell epitope mapping of the VP7 protein in bluetongue virus

Monoclonal antibody and B-cell epitope mapping of the VP7 protein in bluetongue virus

Abstract Bluetongue virus (BTV) VP7 is a group-specific protein that is highly conserved in different serotypes. In this study, BALB/c mice were immunized with purified recombinant BTV-1 VP7 protein expressed in E. coli. Then six monoclonal antibodies (mAbs), 2A7, 2B2, 2B3, 2D3, 2D7, and 2H2, agains...

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Bibliographic Details
Main Authors:	Xin-Bing Hu, Jing Xu, Yu Zhang, Fan-Hua Meng, Zhan-Cheng Tian, Gui-Quan Guan, Jian-Xun Luo, Hong Yin, Jun-Zheng Du
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Series:	Virology Journal
Subjects:	Bluetongue virus VP7 protein Monoclonal antibodies B-cell epitope mapping
Online Access:	https://doi.org/10.1186/s12985-025-02733-7
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