Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection
Fetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality. Development of a vaccine against congenital CMV infection is a major public health priority. Vaccine design is currently focused on strategies that aim to elicit neutrali...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/501801 |
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| author | Mark R. Schleiss |
| author_facet | Mark R. Schleiss |
| author_sort | Mark R. Schleiss |
| collection | DOAJ |
| description | Fetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality. Development of a vaccine against congenital CMV infection is a major public health priority. Vaccine design is currently focused on strategies that aim to elicit neutralizing antibody and T-cell responses, toward the goal of preventing primary or recurrent infection in women of child-bearing age. However, there has been relatively little attention given to understanding the mechanisms of immune protection against acquisition of CMV infection in the fetus and newborn and how this information might be exploited for vaccine design. There has similarly been an insufficient study of what deficits in the immune response to CMV, both for mother and fetus, may increase susceptibility to congenital infection and disease. Protection of the fetus against vertical transmission can likely be achieved by protection of the placenta, which has its own unique immunological milieu, further complicating the analysis of the correlates of protective immunity. In this review, the current state of knowledge about immune effectors of protection against CMV in the maternal, placental, and fetal compartments is reviewed. A better understanding of immune responses that prevent and/or predispose to infection will help in the development of novel vaccine strategies. |
| format | Article |
| id | doaj-art-0218a4f2766045f3acd5323f098dfdc1 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0218a4f2766045f3acd5323f098dfdc12025-02-03T05:59:26ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/501801501801Cytomegalovirus in the Neonate: Immune Correlates of Infection and ProtectionMark R. Schleiss0Department of Pediatrics, University of Minnesota Medical School, Center for Infectious Diseases and Microbiology Translational Research, 2001 6th Street SE, Minneapolis, MN 55455, USAFetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality. Development of a vaccine against congenital CMV infection is a major public health priority. Vaccine design is currently focused on strategies that aim to elicit neutralizing antibody and T-cell responses, toward the goal of preventing primary or recurrent infection in women of child-bearing age. However, there has been relatively little attention given to understanding the mechanisms of immune protection against acquisition of CMV infection in the fetus and newborn and how this information might be exploited for vaccine design. There has similarly been an insufficient study of what deficits in the immune response to CMV, both for mother and fetus, may increase susceptibility to congenital infection and disease. Protection of the fetus against vertical transmission can likely be achieved by protection of the placenta, which has its own unique immunological milieu, further complicating the analysis of the correlates of protective immunity. In this review, the current state of knowledge about immune effectors of protection against CMV in the maternal, placental, and fetal compartments is reviewed. A better understanding of immune responses that prevent and/or predispose to infection will help in the development of novel vaccine strategies.http://dx.doi.org/10.1155/2013/501801 |
| spellingShingle | Mark R. Schleiss Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection Clinical and Developmental Immunology |
| title | Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection |
| title_full | Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection |
| title_fullStr | Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection |
| title_full_unstemmed | Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection |
| title_short | Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection |
| title_sort | cytomegalovirus in the neonate immune correlates of infection and protection |
| url | http://dx.doi.org/10.1155/2013/501801 |
| work_keys_str_mv | AT markrschleiss cytomegalovirusintheneonateimmunecorrelatesofinfectionandprotection |