CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy

CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy

Abstract Background Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8+ T cell subsets usually associated with senescence,...

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Main Authors: Cécile Gonnin, Michelle Leemans, Florence Canoui-Poitrine, Morgane Lebraud, Aurélien Corneau, Louise Roquebert, Philippe Caillet, Pierre Gay, Johanna Canovas, Axelle Histe, Catherine Blanc, Carine El-Sissy, Anis Larbi, Johanne Poisson, Pauline Ober, Pascaline Boudou-Rouquette, Pierre-André Natella, Hélène Vallet, Besma Saadaoui, Richard Layese, Eric Tartour, Elena Paillaud, Clémence Granier
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Immunity & Ageing
Subjects:
Ageing
Senescence
Immune-ageing
Cancer
Tumour
Geriatrics
Online Access:https://doi.org/10.1186/s12979-024-00487-4
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