Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to t...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/937253 |
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| author | Theodore S. Johnson David H. Munn Bernard L. Maria |
| author_facet | Theodore S. Johnson David H. Munn Bernard L. Maria |
| author_sort | Theodore S. Johnson |
| collection | DOAJ |
| description | Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to the survival of the tumor. We review the evidence for functional CNS immune privilege and the impact it has on tumor tolerance. In this paper, we place an emphasis on the role of tumor-infiltrating myeloid cells in maintaining stromal and vascular quiescence, and we underscore the importance of indoleamine 2,3-dioxygenase activity as a myeloid-driven tumor tolerance mechanism. Much remains to be discovered regarding the tolerogenic mechanisms by which CNS tumors avoid immune clearance. Thus, it is an open question whether tumor tolerance in the brain is fundamentally different from that of peripheral sites of tumorigenesis or whether it simply stands as a particularly strong example of such tolerance. |
| format | Article |
| id | doaj-art-0212c2be78774bf0b3e35cf0a6febbbf |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0212c2be78774bf0b3e35cf0a6febbbf2025-02-03T05:53:30ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/937253937253Modulation of Tumor Tolerance in Primary Central Nervous System MalignanciesTheodore S. Johnson0David H. Munn1Bernard L. Maria2Department of Pediatrics, Georgia Health Sciences University, 1120 Fifteenth Street, BT-1852, Augusta, GA 30912, USADepartment of Pediatrics, Georgia Health Sciences University, 1120 Fifteenth Street, BT-1852, Augusta, GA 30912, USADepartment of Pediatrics, Georgia Health Sciences University, 1120 Fifteenth Street, BT-1852, Augusta, GA 30912, USACentral nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to the survival of the tumor. We review the evidence for functional CNS immune privilege and the impact it has on tumor tolerance. In this paper, we place an emphasis on the role of tumor-infiltrating myeloid cells in maintaining stromal and vascular quiescence, and we underscore the importance of indoleamine 2,3-dioxygenase activity as a myeloid-driven tumor tolerance mechanism. Much remains to be discovered regarding the tolerogenic mechanisms by which CNS tumors avoid immune clearance. Thus, it is an open question whether tumor tolerance in the brain is fundamentally different from that of peripheral sites of tumorigenesis or whether it simply stands as a particularly strong example of such tolerance.http://dx.doi.org/10.1155/2012/937253 |
| spellingShingle | Theodore S. Johnson David H. Munn Bernard L. Maria Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies Clinical and Developmental Immunology |
| title | Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies |
| title_full | Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies |
| title_fullStr | Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies |
| title_full_unstemmed | Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies |
| title_short | Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies |
| title_sort | modulation of tumor tolerance in primary central nervous system malignancies |
| url | http://dx.doi.org/10.1155/2012/937253 |
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