THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA
Objective: The neutrophil-to-lymphocyte ratio (NLR) has been recently proposed as a simple, inexpensive prognostic factor in cancer patients. We aimed to investigate the prognostic meaning of pretreatment NLR in patients with lymphoma. Material and Method: Patients aged over 18 years with lymphoma w...
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Istanbul University Press
2021-01-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/1DF73A299220486E9B670155C75BF05B |
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| author | Alpay Medetalibeyoğlu Merve Ateş Mustafa Altınkaynak Gazi Çapar Sena Bayrakdar Timur Selçuk Akpınar Cemil Taşçıoğlu |
| author_facet | Alpay Medetalibeyoğlu Merve Ateş Mustafa Altınkaynak Gazi Çapar Sena Bayrakdar Timur Selçuk Akpınar Cemil Taşçıoğlu |
| author_sort | Alpay Medetalibeyoğlu |
| collection | DOAJ |
| description | Objective: The neutrophil-to-lymphocyte ratio (NLR) has been recently proposed as a simple, inexpensive prognostic factor in cancer patients. We aimed to investigate the prognostic meaning of pretreatment NLR in patients with lymphoma. Material and Method: Patients aged over 18 years with lymphoma who were diagnosed, followed-up and treated between January 2011 and December 2017 in the department of internal medicine were enrolled in this study. The data of 82 patients (62 NHL and 20 HL) were obtained retrospectively. The relationship between the NLR and baseline characteristics, laboratory parameters, prognosis, and survival outcome were evaluated. Results: In patients with HL, the older age group of the patients at the time of diagnosis had a high mortality rate and pleural effusion had a significant negative effect on OS (p=0.008, p=0.035). In patients with NHL, an advanced age, high IPI score, decreased PLT level and elevated beta 2 microglobulin were associated with a high mortality rate (p=0.001, p=0.044, p=0.023, p=0.009). Conclusion: A relation between the NLR and mortality and OS could be not demonstrated in HL patients and NHL patients. The retrospective analysis with a small sample size, late-diagnosed patients population and single-centre study may be the causes of these unexpected results. |
| format | Article |
| id | doaj-art-020fb86d57154fa9b41d0a3c21befedc |
| institution | OA Journals |
| issn | 1305-6441 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-020fb86d57154fa9b41d0a3c21befedc2025-08-20T01:50:22ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412021-01-01841404710.26650/IUITFD.2020.0044123456THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMAAlpay Medetalibeyoğlu0https://orcid.org/0000-0002-5829-9186Merve Ateş1https://orcid.org/0000-0003-1427-8786Mustafa Altınkaynak2https://orcid.org/0000-0002-7768-2746Gazi Çapar3https://orcid.org/0000-0002-9857-0962Sena Bayrakdar4https://orcid.org/0000-0002-4675-185XTimur Selçuk Akpınar5https://orcid.org/0000-0002-9591-4475Cemil Taşçıoğlu6https://orcid.org/0000-0003-3808-6957İstanbul Üniversitesi, İstanbul, TürkiyeMedical University of Vienna, Vienna, Austriaİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: The neutrophil-to-lymphocyte ratio (NLR) has been recently proposed as a simple, inexpensive prognostic factor in cancer patients. We aimed to investigate the prognostic meaning of pretreatment NLR in patients with lymphoma. Material and Method: Patients aged over 18 years with lymphoma who were diagnosed, followed-up and treated between January 2011 and December 2017 in the department of internal medicine were enrolled in this study. The data of 82 patients (62 NHL and 20 HL) were obtained retrospectively. The relationship between the NLR and baseline characteristics, laboratory parameters, prognosis, and survival outcome were evaluated. Results: In patients with HL, the older age group of the patients at the time of diagnosis had a high mortality rate and pleural effusion had a significant negative effect on OS (p=0.008, p=0.035). In patients with NHL, an advanced age, high IPI score, decreased PLT level and elevated beta 2 microglobulin were associated with a high mortality rate (p=0.001, p=0.044, p=0.023, p=0.009). Conclusion: A relation between the NLR and mortality and OS could be not demonstrated in HL patients and NHL patients. The retrospective analysis with a small sample size, late-diagnosed patients population and single-centre study may be the causes of these unexpected results.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/1DF73A299220486E9B670155C75BF05Bhodgkin lymphomanon-hodgkin lymphomaneutrophil/lymphocyte ratioprognosis |
| spellingShingle | Alpay Medetalibeyoğlu Merve Ateş Mustafa Altınkaynak Gazi Çapar Sena Bayrakdar Timur Selçuk Akpınar Cemil Taşçıoğlu THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA İstanbul Tıp Fakültesi Dergisi hodgkin lymphoma non-hodgkin lymphoma neutrophil/lymphocyte ratio prognosis |
| title | THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA |
| title_full | THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA |
| title_fullStr | THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA |
| title_full_unstemmed | THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA |
| title_short | THE PROGNOSTIC SIGNIFICANCE OF NEUTROPHIL-TOLYMPHOCYTE RATIO PATIENTS WITH LYMPHOMA |
| title_sort | prognostic significance of neutrophil tolymphocyte ratio patients with lymphoma |
| topic | hodgkin lymphoma non-hodgkin lymphoma neutrophil/lymphocyte ratio prognosis |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/1DF73A299220486E9B670155C75BF05B |
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