Brain oscillatory activity evoked by chirp modulated tones in healthy children
Aim: To describe the features of cortical oscillatory activity and neuronal synchronization by monitoring responses evoked by chirp-modulated tone (CMT) and look for relationships with cognition in healthy children. Methods: We recruited 23 healthy children, 1–18 years old, assessed their cognitive...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024166303 |
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| author | Nadia Inés Irazabal Elena Urrestarazu Miguel Valencia Oscar Manzanilla Nerea Crespo-Eguilaz María Belén Isaguirre Rocío Sánchez-Carpintero |
| author_facet | Nadia Inés Irazabal Elena Urrestarazu Miguel Valencia Oscar Manzanilla Nerea Crespo-Eguilaz María Belén Isaguirre Rocío Sánchez-Carpintero |
| author_sort | Nadia Inés Irazabal |
| collection | DOAJ |
| description | Aim: To describe the features of cortical oscillatory activity and neuronal synchronization by monitoring responses evoked by chirp-modulated tone (CMT) and look for relationships with cognition in healthy children. Methods: We recruited 23 healthy children, 1–18 years old, assessed their cognitive abilities and recorded the cortical oscillatory activity evoked by CMTs. We obtained descriptive statistics and looked for correlations with cognitive abilities. Results: In the low gamma band, the neuronal synchronization evoked by CMTs increased with age, reaching adult features by 12 years of age (rho = 0.5; p = 0.042). In the high gamma band, neuronal recruitment was greater at younger ages (rho = −0.55; p = 0.029). In four of the six under-6-year-old participants, there was no CMT-evoked response. We found that the greater a child's receptive vocabulary skills, the lower the frequency at which maximal neuronal recruitment occurred (rho = −0.65; p = 0.003). Interpretation: CMT-evoked cortical oscillatory activity is affected by degree of brain maturation and could be a potential biomarker of language-related disability. Our description of the cortical responses evoked by CMTs in healthy children is a step towards recognition of abnormal patterns and the possible use of this approach as a biomarker of brain disorders in children. |
| format | Article |
| id | doaj-art-020fa908e25e4d72ba8b8cebe72551bd |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-020fa908e25e4d72ba8b8cebe72551bd2025-08-20T02:35:00ZengElsevierHeliyon2405-84402024-12-011024e4059910.1016/j.heliyon.2024.e40599Brain oscillatory activity evoked by chirp modulated tones in healthy childrenNadia Inés Irazabal0Elena Urrestarazu1Miguel Valencia2Oscar Manzanilla3Nerea Crespo-Eguilaz4María Belén Isaguirre5Rocío Sánchez-Carpintero6Paediatric Neurology Unit. Department of Paediatrics. Clinica Universidad de Navarra, Pamplona, SpainDepartment of Clinical Neurophysiology. Clinica Universidad de Navarra, Pamplona, Spain; Corresponding author. Department of Clinical Neurophysiology Clínica Universidad de Navarra 31080 Pamplona, Spain.Biomedical Engineering Program, Universidad de Navarra, CIMA, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; Institute of Data Science and Artificial Intelligence, Universidad de Navarra, Pamplona, SpainDepartment of Clinical Neurophysiology. Clinica Universidad de Navarra, Pamplona, SpainPaediatric Neurology Unit. Department of Paediatrics. Clinica Universidad de Navarra, Pamplona, SpainStatistical Consultant, ArgentinaPaediatric Neurology Unit. Department of Paediatrics. Clinica Universidad de Navarra, Pamplona, Spain; IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, SpainAim: To describe the features of cortical oscillatory activity and neuronal synchronization by monitoring responses evoked by chirp-modulated tone (CMT) and look for relationships with cognition in healthy children. Methods: We recruited 23 healthy children, 1–18 years old, assessed their cognitive abilities and recorded the cortical oscillatory activity evoked by CMTs. We obtained descriptive statistics and looked for correlations with cognitive abilities. Results: In the low gamma band, the neuronal synchronization evoked by CMTs increased with age, reaching adult features by 12 years of age (rho = 0.5; p = 0.042). In the high gamma band, neuronal recruitment was greater at younger ages (rho = −0.55; p = 0.029). In four of the six under-6-year-old participants, there was no CMT-evoked response. We found that the greater a child's receptive vocabulary skills, the lower the frequency at which maximal neuronal recruitment occurred (rho = −0.65; p = 0.003). Interpretation: CMT-evoked cortical oscillatory activity is affected by degree of brain maturation and could be a potential biomarker of language-related disability. Our description of the cortical responses evoked by CMTs in healthy children is a step towards recognition of abnormal patterns and the possible use of this approach as a biomarker of brain disorders in children.http://www.sciencedirect.com/science/article/pii/S2405844024166303Brain oscillatory activityHealthy childrenChirpBrain maturationNeurodevelopment biomarker |
| spellingShingle | Nadia Inés Irazabal Elena Urrestarazu Miguel Valencia Oscar Manzanilla Nerea Crespo-Eguilaz María Belén Isaguirre Rocío Sánchez-Carpintero Brain oscillatory activity evoked by chirp modulated tones in healthy children Heliyon Brain oscillatory activity Healthy children Chirp Brain maturation Neurodevelopment biomarker |
| title | Brain oscillatory activity evoked by chirp modulated tones in healthy children |
| title_full | Brain oscillatory activity evoked by chirp modulated tones in healthy children |
| title_fullStr | Brain oscillatory activity evoked by chirp modulated tones in healthy children |
| title_full_unstemmed | Brain oscillatory activity evoked by chirp modulated tones in healthy children |
| title_short | Brain oscillatory activity evoked by chirp modulated tones in healthy children |
| title_sort | brain oscillatory activity evoked by chirp modulated tones in healthy children |
| topic | Brain oscillatory activity Healthy children Chirp Brain maturation Neurodevelopment biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024166303 |
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