Case of severe thrombocytopenia with recurrent extensive deep vein thrombosis due to antiphospholipid syndrome, management challenge

Case of severe thrombocytopenia with recurrent extensive deep vein thrombosis due to antiphospholipid syndrome, management challenge

Key Clinical Message Severe thrombocytopenia in secondary antiphospholipid syndrome (APS) presents a significant management challenge. This case highlights the complexity of managing APS‐related thrombocytopenia, requiring a nuanced approach to balancing bleeding and thrombotic risks. Intravenous im...

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Bibliographic Details
Main Authors: Bassem Al Hariri, Gaydaa Ali Ahmed Ali, Arwa Elfatih Mohamed Ali, Mohamed Elfatih MohamedAli, Feroz Jenner Poolakundan, Muhammad Sharif, Memon Noor Illahi
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical Case Reports
Subjects:
anticoagulation
antiphospholipid syndrome
APS
deep vein thrombosis
DVT
thrombocytopenia
Online Access:https://doi.org/10.1002/ccr3.9430
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Summary:Key Clinical Message Severe thrombocytopenia in secondary antiphospholipid syndrome (APS) presents a significant management challenge. This case highlights the complexity of managing APS‐related thrombocytopenia, requiring a nuanced approach to balancing bleeding and thrombotic risks. Intravenous immunoglobulin, followed by a short course of steroids, successfully increased platelet counts without adverse bleeding or thrombotic events. Initiating therapeutic anticoagulation with Warfarin was delayed until platelet counts exceeded 50 × 10^3/μL, emphasizing the cautious approach required in such cases to mitigate thrombotic risks while avoiding bleeding complications.
ISSN:2050-0904

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