Successful treatment of two cases with Philadelphia-chromosome positive acute lymphoblastic leukemia who relapsed after allogeneic stem cell transplantation and the treatments with novel immunotherapies and ponatinib

Successful treatment of two cases with Philadelphia-chromosome positive acute lymphoblastic leukemia who relapsed after allogeneic stem cell transplantation and the treatments with novel immunotherapies and ponatinib

The outcomes of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) resistant to new drugs such as tyrosine kinase inhibitors, inotuzumab ozogamicin (InO) and blinatumomab are dismal. We treated two cases of Ph+ALL resistant to these drugs that achieved long-term survival...

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Bibliographic Details
Main Authors: Takayoshi Tachibana, Masatsugu Tanaka, Yuma Noguchi, Yuho Najima, Daichi Sadato, Yuka Harada, Yotaro Tamai, Noriko Doki, Hideaki Nakajima
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Hematology
Subjects:
Philadelphia-positive acute lymphoblastic leukemia
relapse/refractory
ponatinib
inotuzumab ozogamicin
blinatumomab
clofarabin
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2024.2360843
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