Smoking and serological response to influenza vaccine
Cigarette smoking confers additional risk from influenza. This study assessed the effect of smoking on humoral immune response to influenza vaccine. Adults ≥50 y of age were enrolled during the 2011–2016 influenza vaccination seasons in an observational prospective study. Non-fasting whole blood sam...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2404752 |
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| author | Won Suk Choi Mary Patricia Nowalk Krissy Moehling Geffel Michael Susick Sean Saul Chyongchiou Jeng Lin Ted M. Ross Richard K. Zimmerman |
| author_facet | Won Suk Choi Mary Patricia Nowalk Krissy Moehling Geffel Michael Susick Sean Saul Chyongchiou Jeng Lin Ted M. Ross Richard K. Zimmerman |
| author_sort | Won Suk Choi |
| collection | DOAJ |
| description | Cigarette smoking confers additional risk from influenza. This study assessed the effect of smoking on humoral immune response to influenza vaccine. Adults ≥50 y of age were enrolled during the 2011–2016 influenza vaccination seasons in an observational prospective study. Non-fasting whole blood samples for hemagglutination inhibition (HAI) assays were obtained from participants at pre- and 28 d post-clinically administered, trivalent influenza vaccination. Among 273 participants, 133 subjects self-reported as never smokers, 87 as ex-smokers, and 53 as current smokers. Postvaccination geometric mean HAI titers were significantly higher among smokers for A/H1N1 (p = .031) and A/H3N2 (p = .001). Relative to never smokers, smoking was independently related to seroconversion to A/H1N1, A/H3N2 and B. The adjusted odd ratios (ORs) were 5.2 [95% confidence interval (CI), 2.3, 11.5] for seroconversion to A/H1N1, 5.4 (95% CI, 2.4, 12.1) for A/H3N2, and 2.7 (95% CI, 1.3, 5.7) for B. Smoking was also independently related to seroprotection to A/H1N1, A/H3N2 and B. The ORs were 3.6 (95% CI, 1.6, 8.08) for seroprotection to A/H1N1 in smokers, 2.7 (95% CI, 1.14, 6.5) for A/H3N2, and 2.5 (95% CI, 1.1, 5.7) for B. Although the mechanism is unclear, smokers showed a better immune response to influenza vaccination than never smokers and ex-smokers. The results can be used to emphasize the value of influenza vaccination for smokers. |
| format | Article |
| id | doaj-art-020456daf8df45cc886bccee9712667e |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-020456daf8df45cc886bccee9712667e2025-08-20T02:34:25ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2404752Smoking and serological response to influenza vaccineWon Suk Choi0Mary Patricia Nowalk1Krissy Moehling Geffel2Michael Susick3Sean Saul4Chyongchiou Jeng Lin5Ted M. Ross6Richard K. Zimmerman7Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of KoreaDepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USADepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USADepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USADepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USADepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USACenter for Vaccines and Immunology, University of Georgia, Athens, GA, USADepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USACigarette smoking confers additional risk from influenza. This study assessed the effect of smoking on humoral immune response to influenza vaccine. Adults ≥50 y of age were enrolled during the 2011–2016 influenza vaccination seasons in an observational prospective study. Non-fasting whole blood samples for hemagglutination inhibition (HAI) assays were obtained from participants at pre- and 28 d post-clinically administered, trivalent influenza vaccination. Among 273 participants, 133 subjects self-reported as never smokers, 87 as ex-smokers, and 53 as current smokers. Postvaccination geometric mean HAI titers were significantly higher among smokers for A/H1N1 (p = .031) and A/H3N2 (p = .001). Relative to never smokers, smoking was independently related to seroconversion to A/H1N1, A/H3N2 and B. The adjusted odd ratios (ORs) were 5.2 [95% confidence interval (CI), 2.3, 11.5] for seroconversion to A/H1N1, 5.4 (95% CI, 2.4, 12.1) for A/H3N2, and 2.7 (95% CI, 1.3, 5.7) for B. Smoking was also independently related to seroprotection to A/H1N1, A/H3N2 and B. The ORs were 3.6 (95% CI, 1.6, 8.08) for seroprotection to A/H1N1 in smokers, 2.7 (95% CI, 1.14, 6.5) for A/H3N2, and 2.5 (95% CI, 1.1, 5.7) for B. Although the mechanism is unclear, smokers showed a better immune response to influenza vaccination than never smokers and ex-smokers. The results can be used to emphasize the value of influenza vaccination for smokers.https://www.tandfonline.com/doi/10.1080/21645515.2024.2404752Influenzavaccineimmunogenicityhemagglutination inhibition testssmoking |
| spellingShingle | Won Suk Choi Mary Patricia Nowalk Krissy Moehling Geffel Michael Susick Sean Saul Chyongchiou Jeng Lin Ted M. Ross Richard K. Zimmerman Smoking and serological response to influenza vaccine Human Vaccines & Immunotherapeutics Influenza vaccine immunogenicity hemagglutination inhibition tests smoking |
| title | Smoking and serological response to influenza vaccine |
| title_full | Smoking and serological response to influenza vaccine |
| title_fullStr | Smoking and serological response to influenza vaccine |
| title_full_unstemmed | Smoking and serological response to influenza vaccine |
| title_short | Smoking and serological response to influenza vaccine |
| title_sort | smoking and serological response to influenza vaccine |
| topic | Influenza vaccine immunogenicity hemagglutination inhibition tests smoking |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2404752 |
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