Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat
Aims. In spastic subjects, lidocaine is often used to induce a block predictive of the result provided by subsequent surgery. Lidocaine has been demonstrated to inhibit the Hoffmann (H) reflex to a greater extent than the direct motor (M) response induced by electrical stimulation, but the timecours...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/912716 |
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| author | Kévin Buffenoir Philippe Decq Chantal Pérot |
| author_facet | Kévin Buffenoir Philippe Decq Chantal Pérot |
| author_sort | Kévin Buffenoir |
| collection | DOAJ |
| description | Aims. In spastic subjects, lidocaine is often used to induce a block predictive of the result provided by subsequent surgery. Lidocaine has been demonstrated to inhibit the Hoffmann (H) reflex to a greater extent than the direct motor (M) response induced by electrical stimulation, but the timecourse of these responses has not been investigated. Methods. An animal (rat) model of the effects of lidocaine on M and H responses was therefore developed to assess this time course. M and H responses were recorded in 18 adult rats before and after application of lidocaine to the sciatic nerve. Results. Two to five minutes after lidocaine injection, M responses were markedly reduced (mean reduction of 44%) and H reflexes were completely abolished. Changes were observed more rapidly for the H reflex. The effects of lidocaine then persisted for 100 minutes. The effect of lidocaine was therefore more prolonged on the H reflex than on the M response. Conclusion. This study confirms that lidocaine blocks not only alpha motoneurons but also Ia afferent fibres responsible for the H reflex. The authors describe, for the first time, the detailed time course of the effect of lidocaine on direct or reflex activation of motoneurons in the rat. |
| format | Article |
| id | doaj-art-0202e1788b004fa2a0228eb89de3a123 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0202e1788b004fa2a0228eb89de3a1232025-08-20T02:01:46ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/912716912716Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the RatKévin Buffenoir0Philippe Decq1Chantal Pérot2Université de Technologie de Compiègne, CNRS UMR 7338 Biomécanique et Bioingénierie, BP 20529, 60205 Compiègne, FranceEquipe Biomécanique et Système Nerveux. LBM ENSAM ParisTech, Faculté de Médecine PARIS 12, Assistance Publique—Hôpitaux de Paris, Service de Neurochirurgie, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, FranceUniversité de Technologie de Compiègne, CNRS UMR 7338 Biomécanique et Bioingénierie, BP 20529, 60205 Compiègne, FranceAims. In spastic subjects, lidocaine is often used to induce a block predictive of the result provided by subsequent surgery. Lidocaine has been demonstrated to inhibit the Hoffmann (H) reflex to a greater extent than the direct motor (M) response induced by electrical stimulation, but the timecourse of these responses has not been investigated. Methods. An animal (rat) model of the effects of lidocaine on M and H responses was therefore developed to assess this time course. M and H responses were recorded in 18 adult rats before and after application of lidocaine to the sciatic nerve. Results. Two to five minutes after lidocaine injection, M responses were markedly reduced (mean reduction of 44%) and H reflexes were completely abolished. Changes were observed more rapidly for the H reflex. The effects of lidocaine then persisted for 100 minutes. The effect of lidocaine was therefore more prolonged on the H reflex than on the M response. Conclusion. This study confirms that lidocaine blocks not only alpha motoneurons but also Ia afferent fibres responsible for the H reflex. The authors describe, for the first time, the detailed time course of the effect of lidocaine on direct or reflex activation of motoneurons in the rat.http://dx.doi.org/10.1155/2013/912716 |
| spellingShingle | Kévin Buffenoir Philippe Decq Chantal Pérot Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat The Scientific World Journal |
| title | Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat |
| title_full | Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat |
| title_fullStr | Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat |
| title_full_unstemmed | Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat |
| title_short | Time Course of the Soleus M Response and H Reflex after Lidocaine Tibial Nerve Block in the Rat |
| title_sort | time course of the soleus m response and h reflex after lidocaine tibial nerve block in the rat |
| url | http://dx.doi.org/10.1155/2013/912716 |
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