The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial Cancer
OBJECTIVES: The primary goal of the cohort was to show the relationship between systemic inflammatory index (SII) and prognostic nutritional index (PNI) values and the prognostic factors of endometrial cancer (EC), especially lymph node (LN) involvement, and lymphovascular space invasion (LVSI), wh...
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Medical Network
2024-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1490 |
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| _version_ | 1823857322740416512 |
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| author | Varol Gulseren Mine Daggez Ertugrul Sen Mehmet Dolanbay Fulya Caglı Bulent Ozcelik İbrahim Serdar Serin Kemal Gungorduk |
| author_facet | Varol Gulseren Mine Daggez Ertugrul Sen Mehmet Dolanbay Fulya Caglı Bulent Ozcelik İbrahim Serdar Serin Kemal Gungorduk |
| author_sort | Varol Gulseren |
| collection | DOAJ |
| description |
OBJECTIVES: The primary goal of the cohort was to show the relationship between systemic inflammatory index (SII) and prognostic nutritional index (PNI) values and the prognostic factors of endometrial cancer (EC), especially lymph node (LN) involvement, and lymphovascular space invasion (LVSI), which can not generally be evaluated preoperatively.
STUDY DESIGN: This is a retrospective cohort study on reviews of patient records who were diagnosed with EC and underwent treatment between January 2014 and 2021. Complete blood counts and albumin level measurements were performed within 2 weeks before treatment
RESULTS: Two hundred twenty-seven patients with endometrioid type EC were included in the cohort. The mean follow-up was 35.4 ± 19.6 months. LVSI positivity was 8.2% in the presence of low SII and 44.1% in the presence of high SII (p<0.001). LVSI positivity was 23.3% in the presence of low PNI and 11.1% in the presence of high PNI (p=0.025). Low and high PNI values do not affect disease-free (DFS) and overall survival (OS) significantly. 5-year mean DFS and OS differ significantly with low and high SII values.
CONCLUSİON: SII and PNI values can be used to predict the presence of LVSI in the preoperative period, and to determine the extent of LN dissection and the surgical procedure Patients with high SII values had worse survival outcomes.
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| format | Article |
| id | doaj-art-01fd36adf1444ddeb7ac7080d09f1e80 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-01fd36adf1444ddeb7ac7080d09f1e802025-02-11T21:19:02ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182024-12-0130310.21613/GORM.2023.1490The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial CancerVarol Gulseren0Mine Daggez1Ertugrul Sen2Mehmet Dolanbay3Fulya Caglı4Bulent Ozcelik5İbrahim Serdar Serin6Kemal Gungorduk7Erciyes Universityerciyes universityerciyes universityerciyes universityerciyes universityerciyes universityerciyes universityMuğla Sıtkı Koçman University OBJECTIVES: The primary goal of the cohort was to show the relationship between systemic inflammatory index (SII) and prognostic nutritional index (PNI) values and the prognostic factors of endometrial cancer (EC), especially lymph node (LN) involvement, and lymphovascular space invasion (LVSI), which can not generally be evaluated preoperatively. STUDY DESIGN: This is a retrospective cohort study on reviews of patient records who were diagnosed with EC and underwent treatment between January 2014 and 2021. Complete blood counts and albumin level measurements were performed within 2 weeks before treatment RESULTS: Two hundred twenty-seven patients with endometrioid type EC were included in the cohort. The mean follow-up was 35.4 ± 19.6 months. LVSI positivity was 8.2% in the presence of low SII and 44.1% in the presence of high SII (p<0.001). LVSI positivity was 23.3% in the presence of low PNI and 11.1% in the presence of high PNI (p=0.025). Low and high PNI values do not affect disease-free (DFS) and overall survival (OS) significantly. 5-year mean DFS and OS differ significantly with low and high SII values. CONCLUSİON: SII and PNI values can be used to predict the presence of LVSI in the preoperative period, and to determine the extent of LN dissection and the surgical procedure Patients with high SII values had worse survival outcomes. https://gorm.com.tr/index.php/GORM/article/view/1490Endometrial cancerLymph node Lymphovascular space invasionPrognostic nutritional indexSystemic inflammatory index |
| spellingShingle | Varol Gulseren Mine Daggez Ertugrul Sen Mehmet Dolanbay Fulya Caglı Bulent Ozcelik İbrahim Serdar Serin Kemal Gungorduk The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial Cancer Gynecology Obstetrics & Reproductive Medicine Endometrial cancer Lymph node Lymphovascular space invasion Prognostic nutritional index Systemic inflammatory index |
| title | The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial Cancer |
| title_full | The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial Cancer |
| title_fullStr | The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial Cancer |
| title_full_unstemmed | The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial Cancer |
| title_short | The Effect of Prognostic Nutritional Index and Systemic Inflammatory Index in Endometrioid Type Endometrial Cancer |
| title_sort | effect of prognostic nutritional index and systemic inflammatory index in endometrioid type endometrial cancer |
| topic | Endometrial cancer Lymph node Lymphovascular space invasion Prognostic nutritional index Systemic inflammatory index |
| url | https://gorm.com.tr/index.php/GORM/article/view/1490 |
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