Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.

SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of infection, can inform clinical measures and interventions such as test-base...

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Main Authors: Stephen M Kissler, Joseph R Fauver, Christina Mack, Scott W Olesen, Caroline Tai, Kristin Y Shiue, Chaney C Kalinich, Sarah Jednak, Isabel M Ott, Chantal B F Vogels, Jay Wohlgemuth, James Weisberger, John DiFiori, Deverick J Anderson, Jimmie Mancell, David D Ho, Nathan D Grubaugh, Yonatan H Grad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001333&type=printable
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author Stephen M Kissler
Joseph R Fauver
Christina Mack
Scott W Olesen
Caroline Tai
Kristin Y Shiue
Chaney C Kalinich
Sarah Jednak
Isabel M Ott
Chantal B F Vogels
Jay Wohlgemuth
James Weisberger
John DiFiori
Deverick J Anderson
Jimmie Mancell
David D Ho
Nathan D Grubaugh
Yonatan H Grad
author_facet Stephen M Kissler
Joseph R Fauver
Christina Mack
Scott W Olesen
Caroline Tai
Kristin Y Shiue
Chaney C Kalinich
Sarah Jednak
Isabel M Ott
Chantal B F Vogels
Jay Wohlgemuth
James Weisberger
John DiFiori
Deverick J Anderson
Jimmie Mancell
David D Ho
Nathan D Grubaugh
Yonatan H Grad
author_sort Stephen M Kissler
collection DOAJ
description SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of infection, can inform clinical measures and interventions such as test-based screening. We used prospective longitudinal quantitative reverse transcription PCR testing to measure the viral RNA trajectories for 68 individuals during the resumption of the 2019-2020 National Basketball Association season. For 46 individuals with acute infections, we inferred the peak viral concentration and the duration of the viral proliferation and clearance phases. According to our mathematical model, we found that viral RNA concentrations peaked an average of 3.3 days (95% credible interval [CI] 2.5, 4.2) after first possible detectability at a cycle threshold value of 22.3 (95% CI 20.5, 23.9). The viral clearance phase lasted longer for symptomatic individuals (10.9 days [95% CI 7.9, 14.4]) than for asymptomatic individuals (7.8 days [95% CI 6.1, 9.7]). A second test within 2 days after an initial positive PCR test substantially improves certainty about a patient's infection stage. The effective sensitivity of a test intended to identify infectious individuals declines substantially with test turnaround time. These findings indicate that SARS-CoV-2 viral concentrations peak rapidly regardless of symptoms. Sequential tests can help reveal a patient's progress through infection stages. Frequent, rapid-turnaround testing is needed to effectively screen individuals before they become infectious.
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spelling doaj-art-01f7e7f6f2cf4783ad7919da296f05872025-08-20T02:18:24ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852021-07-01197e300133310.1371/journal.pbio.3001333Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.Stephen M KisslerJoseph R FauverChristina MackScott W OlesenCaroline TaiKristin Y ShiueChaney C KalinichSarah JednakIsabel M OttChantal B F VogelsJay WohlgemuthJames WeisbergerJohn DiFioriDeverick J AndersonJimmie MancellDavid D HoNathan D GrubaughYonatan H GradSARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of infection, can inform clinical measures and interventions such as test-based screening. We used prospective longitudinal quantitative reverse transcription PCR testing to measure the viral RNA trajectories for 68 individuals during the resumption of the 2019-2020 National Basketball Association season. For 46 individuals with acute infections, we inferred the peak viral concentration and the duration of the viral proliferation and clearance phases. According to our mathematical model, we found that viral RNA concentrations peaked an average of 3.3 days (95% credible interval [CI] 2.5, 4.2) after first possible detectability at a cycle threshold value of 22.3 (95% CI 20.5, 23.9). The viral clearance phase lasted longer for symptomatic individuals (10.9 days [95% CI 7.9, 14.4]) than for asymptomatic individuals (7.8 days [95% CI 6.1, 9.7]). A second test within 2 days after an initial positive PCR test substantially improves certainty about a patient's infection stage. The effective sensitivity of a test intended to identify infectious individuals declines substantially with test turnaround time. These findings indicate that SARS-CoV-2 viral concentrations peak rapidly regardless of symptoms. Sequential tests can help reveal a patient's progress through infection stages. Frequent, rapid-turnaround testing is needed to effectively screen individuals before they become infectious.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001333&type=printable
spellingShingle Stephen M Kissler
Joseph R Fauver
Christina Mack
Scott W Olesen
Caroline Tai
Kristin Y Shiue
Chaney C Kalinich
Sarah Jednak
Isabel M Ott
Chantal B F Vogels
Jay Wohlgemuth
James Weisberger
John DiFiori
Deverick J Anderson
Jimmie Mancell
David D Ho
Nathan D Grubaugh
Yonatan H Grad
Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.
PLoS Biology
title Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.
title_full Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.
title_fullStr Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.
title_full_unstemmed Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.
title_short Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.
title_sort viral dynamics of acute sars cov 2 infection and applications to diagnostic and public health strategies
url https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001333&type=printable
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