Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis

Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis

Abstract Background/aims The molecular mechanisms driving nonalcoholic steatohepatitis (NASH) progression are poorly understood. This research examines the involvement of chaperone‐mediated autophagy (CMA) in NASH progression. Methods Hepatic CMA activity was analysed in NASH mice and patients. Lyso...

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Bibliographic Details
Main Authors: Shuoyi Ma, Erzhuo Xia, Miao Zhang, Yinan Hu, Siyuan Tian, Xiaohong Zheng, Bo Li, Gang Ma, Rui Su, Keshuai Sun, Qingling Fan, Fangfang Yang, Guanya Guo, Changcun Guo, Yulong Shang, Xinmin Zhou, Xia Zhou, Jingbo Wang, Ying Han
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
chaperone‐mediated autophagy
cholesterol
endoplasmic reticulum stress
FOXM1
nonalcoholic steatohepatitis
Online Access:https://doi.org/10.1002/ctm2.70202
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