Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy
PurposeTo evaluate the safety and efficacy of CT-guided lung biopsy combined with microwave ablation (MWA) for solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.Materials and methodsThis retrospective study included 37 post-radical surgery breast cancer pa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525114/full |
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| author | Chao Xing Peishun Li Sen Yang Qirong Man Xusheng Zhang Qianqian Yuan Miaomiao Hu Yunling Bai Kaixian Zhang |
| author_facet | Chao Xing Peishun Li Sen Yang Qirong Man Xusheng Zhang Qianqian Yuan Miaomiao Hu Yunling Bai Kaixian Zhang |
| author_sort | Chao Xing |
| collection | DOAJ |
| description | PurposeTo evaluate the safety and efficacy of CT-guided lung biopsy combined with microwave ablation (MWA) for solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.Materials and methodsThis retrospective study included 37 post-radical surgery breast cancer patients with solitary suspected malignant pulmonary nodules, treated with CT-guided lung biopsy and MWA between January 2014 and December 2018. Institutional review board approval was obtained. Clinical outcomes and complications were analyzed.ResultsPathological results identified primary lung cancer in 5 patients (13.5%, 5/37) and metastatic invasive ductal carcinoma (breast origin) in 30 patients (81.1%, 30/37). Major complications included pneumothorax (n=8, 21.6%), chest pain (n=6, 16.2%), and hemoptysis (n=4, 10.8%). For metastatic cases, 2-, 3-, and 5-year survival rates were 86.2%, 58.3%, and 35.3%, respectively. The median progression-free survival after MWA was 35 months (range: 4–72; 95% CI: 24.53–46.48), and median overall survival was 44 months (95% CI: 32.55–55.45).ConclusionCT-guided lung biopsy combined with MWA is a safe and effective approach for managing solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients. |
| format | Article |
| id | doaj-art-01f68e057e0542d6ab8ccb9740b9bbdf |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-01f68e057e0542d6ab8ccb9740b9bbdf2025-08-20T03:35:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15251141525114Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomyChao XingPeishun LiSen YangQirong ManXusheng ZhangQianqian YuanMiaomiao HuYunling BaiKaixian ZhangPurposeTo evaluate the safety and efficacy of CT-guided lung biopsy combined with microwave ablation (MWA) for solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.Materials and methodsThis retrospective study included 37 post-radical surgery breast cancer patients with solitary suspected malignant pulmonary nodules, treated with CT-guided lung biopsy and MWA between January 2014 and December 2018. Institutional review board approval was obtained. Clinical outcomes and complications were analyzed.ResultsPathological results identified primary lung cancer in 5 patients (13.5%, 5/37) and metastatic invasive ductal carcinoma (breast origin) in 30 patients (81.1%, 30/37). Major complications included pneumothorax (n=8, 21.6%), chest pain (n=6, 16.2%), and hemoptysis (n=4, 10.8%). For metastatic cases, 2-, 3-, and 5-year survival rates were 86.2%, 58.3%, and 35.3%, respectively. The median progression-free survival after MWA was 35 months (range: 4–72; 95% CI: 24.53–46.48), and median overall survival was 44 months (95% CI: 32.55–55.45).ConclusionCT-guided lung biopsy combined with MWA is a safe and effective approach for managing solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.https://www.frontiersin.org/articles/10.3389/fonc.2025.1525114/fulllung biopsymicrowave ablation (MWA)pulmonary nodulebreast cancerlung metastases |
| spellingShingle | Chao Xing Peishun Li Sen Yang Qirong Man Xusheng Zhang Qianqian Yuan Miaomiao Hu Yunling Bai Kaixian Zhang Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy Frontiers in Oncology lung biopsy microwave ablation (MWA) pulmonary nodule breast cancer lung metastases |
| title | Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy |
| title_full | Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy |
| title_fullStr | Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy |
| title_full_unstemmed | Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy |
| title_short | Investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy |
| title_sort | investigation of the efficacy and safety of lung biopsy plus microwave ablation for a solitary suspected malignant pulmonary nodule after radical mastectomy |
| topic | lung biopsy microwave ablation (MWA) pulmonary nodule breast cancer lung metastases |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525114/full |
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