Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms

Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms

Abstract In synucleinopathies, α-synuclein oligomers (OSyn) appear to be associated with neurodegeneration, neurotoxicity, and proinflammatory responses, even at low concentrations, suggesting their pivotal role in the pathogenesis of Parkinson’s disease (PD). We utilized a rat model of synucleinopa...

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Main Authors: Laura Bellingacci, Miriam Sciaccaluga, Alfredo Megaro, Antonella Cardinale, Jacopo Canonichesi, Maria De Carluccio, Roberta Mastrantonio, Cinzia Costa, Massimiliano Di Filippo, Alessandro Usiello, Maria Teresa Viscomi, Paolo Calabresi, Alessandro Tozzi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01075-z
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