The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis

Aim: To evaluate the clinic-pathological features and prognostic value regarding PSMD14 in cancers.Materials & methods: Literature was gathered from public databases until 22 June 2023 to analyze data on survival rates and clinicopathological characteristics associated with PSMD14. TCGA and GEO...

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Main Authors: Shu-Yi Dong, Shuxin Ding, Zhen Meng, Bo Zou
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Future Science OA
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Online Access:https://www.tandfonline.com/doi/10.1080/20565623.2024.2409054
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author Shu-Yi Dong
Shuxin Ding
Zhen Meng
Bo Zou
author_facet Shu-Yi Dong
Shuxin Ding
Zhen Meng
Bo Zou
author_sort Shu-Yi Dong
collection DOAJ
description Aim: To evaluate the clinic-pathological features and prognostic value regarding PSMD14 in cancers.Materials & methods: Literature was gathered from public databases until 22 June 2023 to analyze data on survival rates and clinicopathological characteristics associated with PSMD14. TCGA and GEO data were also utilized for validation.Results: Eight reports on seven types of tumors showed that high PSMD14 expression was linked to poorer overall survival and disease-free survival. PSMD14 expression also correlated with larger tumor size, differentiation and metastasis, as well as the effectiveness of various chemotherapy drugs.Conclusion: PSMD14 could serve as a potential biomarker of poor prognosis in cancers, including lung cancer, head and neck squamous cell carcinoma, ovarian cancer, breast cancer and hepatocellular carcinoma.
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spelling doaj-art-01f2a0293b1a4b6286f9ba059ef1e0882025-08-20T02:41:39ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.1080/20565623.2024.2409054The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysisShu-Yi Dong0Shuxin Ding1Zhen Meng2Bo Zou3Department of Oral & Maxillofacial Surgery, Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong, P. R. ChinaDepartment of Oral & Maxillofacial Surgery, Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong, P. R. ChinaDepartment of Oral & Maxillofacial Surgery, Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong, P. R. ChinaDepartment of Oral & Maxillofacial Surgery, Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong, P. R. ChinaAim: To evaluate the clinic-pathological features and prognostic value regarding PSMD14 in cancers.Materials & methods: Literature was gathered from public databases until 22 June 2023 to analyze data on survival rates and clinicopathological characteristics associated with PSMD14. TCGA and GEO data were also utilized for validation.Results: Eight reports on seven types of tumors showed that high PSMD14 expression was linked to poorer overall survival and disease-free survival. PSMD14 expression also correlated with larger tumor size, differentiation and metastasis, as well as the effectiveness of various chemotherapy drugs.Conclusion: PSMD14 could serve as a potential biomarker of poor prognosis in cancers, including lung cancer, head and neck squamous cell carcinoma, ovarian cancer, breast cancer and hepatocellular carcinoma.https://www.tandfonline.com/doi/10.1080/20565623.2024.2409054bioinformatical analysiscancermeta-analysisPSMD14
spellingShingle Shu-Yi Dong
Shuxin Ding
Zhen Meng
Bo Zou
The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis
Future Science OA
bioinformatical analysis
cancer
meta-analysis
PSMD14
title The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis
title_full The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis
title_fullStr The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis
title_full_unstemmed The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis
title_short The clinicopathological and prognostic significance of PSMD14 in cancers based on bioinformatics and meta-analysis
title_sort clinicopathological and prognostic significance of psmd14 in cancers based on bioinformatics and meta analysis
topic bioinformatical analysis
cancer
meta-analysis
PSMD14
url https://www.tandfonline.com/doi/10.1080/20565623.2024.2409054
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