High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional study
Abstract No previous study has examined the association of an acid-base imbalanced diet to autoimmune bullous disease. The present study aimed to investigate the association between dietary acid load (DAL) as either potential renal acid load (PRAL) and net endogenous acid production (NEAP) intake on...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-78709-4 |
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| author | Maryam Fallah Banafsheh Jafari Azad Anahita Najafi Zahra Esmaeily Kamran Balighi Maryam Daneshpazhooh Soraiya Ebrahimpour-Koujan |
| author_facet | Maryam Fallah Banafsheh Jafari Azad Anahita Najafi Zahra Esmaeily Kamran Balighi Maryam Daneshpazhooh Soraiya Ebrahimpour-Koujan |
| author_sort | Maryam Fallah |
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| description | Abstract No previous study has examined the association of an acid-base imbalanced diet to autoimmune bullous disease. The present study aimed to investigate the association between dietary acid load (DAL) as either potential renal acid load (PRAL) and net endogenous acid production (NEAP) intake on the odds of high-severity Pemphigus Vulgaris (PV) disease in adult Iranian patients to fill this gap. A cross-sectional study was conducted on 138 patients, aged 18–65 years with confirmed diagnoses of PV in a referral university center for autoimmune bullous diseases. The dietary intakes of all patients during the last year before enrollment in the study were assessed using a 168-item semi-quantitative food frequency questionnaire. Dietary acid load was calculated based on the PRAL and NEAP scores. To assess PV severity, the pemphigus disease area index (PDAI) score was used. Logistic regression was used to evaluate the association between DAL and PDAI. A positive association was observed between PRAL and PDAI score in the crude (adjusted R2 = 0.088, B = 6.88, P < 0.0001) and all other adjusted models, as well as the crude model for NEAP (adjusted R2 = 0.037, B = 4.72, P = 0.013). In terms of adherence to NEAP and PRAL, those in the top tertile of PRAL and NEAP had a higher vulnerability for severe PV in unadjusted (OR = 5.18, 95% (CI) 2.19–12.25) and (OR = 2.48, 95% (CI) 1.08–5.68) respectively. In the present study, we found a significant direct association between DAL and severity of disease in PV patients. Further studies are required to confirm these findings. |
| format | Article |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-01e4836646cc45d38642f5e6487198282025-08-20T02:31:03ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-78709-4High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional studyMaryam Fallah0Banafsheh Jafari Azad1Anahita Najafi2Zahra Esmaeily3Kamran Balighi4Maryam Daneshpazhooh5Soraiya Ebrahimpour-Koujan6Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesAutoimmune Bullous Diseases Research Center, Tehran University of Medical SciencesAutoimmune Bullous Diseases Research Center, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesAbstract No previous study has examined the association of an acid-base imbalanced diet to autoimmune bullous disease. The present study aimed to investigate the association between dietary acid load (DAL) as either potential renal acid load (PRAL) and net endogenous acid production (NEAP) intake on the odds of high-severity Pemphigus Vulgaris (PV) disease in adult Iranian patients to fill this gap. A cross-sectional study was conducted on 138 patients, aged 18–65 years with confirmed diagnoses of PV in a referral university center for autoimmune bullous diseases. The dietary intakes of all patients during the last year before enrollment in the study were assessed using a 168-item semi-quantitative food frequency questionnaire. Dietary acid load was calculated based on the PRAL and NEAP scores. To assess PV severity, the pemphigus disease area index (PDAI) score was used. Logistic regression was used to evaluate the association between DAL and PDAI. A positive association was observed between PRAL and PDAI score in the crude (adjusted R2 = 0.088, B = 6.88, P < 0.0001) and all other adjusted models, as well as the crude model for NEAP (adjusted R2 = 0.037, B = 4.72, P = 0.013). In terms of adherence to NEAP and PRAL, those in the top tertile of PRAL and NEAP had a higher vulnerability for severe PV in unadjusted (OR = 5.18, 95% (CI) 2.19–12.25) and (OR = 2.48, 95% (CI) 1.08–5.68) respectively. In the present study, we found a significant direct association between DAL and severity of disease in PV patients. Further studies are required to confirm these findings.https://doi.org/10.1038/s41598-024-78709-4Pemphigus VulgarisDietary acid loadDALPRALNEAPPDAI |
| spellingShingle | Maryam Fallah Banafsheh Jafari Azad Anahita Najafi Zahra Esmaeily Kamran Balighi Maryam Daneshpazhooh Soraiya Ebrahimpour-Koujan High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional study Scientific Reports Pemphigus Vulgaris Dietary acid load DAL PRAL NEAP PDAI |
| title | High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional study |
| title_full | High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional study |
| title_fullStr | High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional study |
| title_full_unstemmed | High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional study |
| title_short | High dietary acid load predicts severity of autoimmune skin disease: a cross-sectional study |
| title_sort | high dietary acid load predicts severity of autoimmune skin disease a cross sectional study |
| topic | Pemphigus Vulgaris Dietary acid load DAL PRAL NEAP PDAI |
| url | https://doi.org/10.1038/s41598-024-78709-4 |
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