SDC1 is a critical transmembrane proteoglycan in breast cancer
Abstract There has been an increasing incidence of breast cancer around the world in recent years. As a burgeoning model of diagnosis and treatment, precision medicine has become a new trend in breast cancer management. Dysregulated glycometabolism is well established as a tumor feature. SDC1 is a g...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03840-z |
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| _version_ | 1850273407834259456 |
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| author | Yingying Mei Lantao Zhao Na Zhou |
| author_facet | Yingying Mei Lantao Zhao Na Zhou |
| author_sort | Yingying Mei |
| collection | DOAJ |
| description | Abstract There has been an increasing incidence of breast cancer around the world in recent years. As a burgeoning model of diagnosis and treatment, precision medicine has become a new trend in breast cancer management. Dysregulated glycometabolism is well established as a tumor feature. SDC1 is a glycometabolism-related gene and participates in the progression, metastasis, resistance and recurrence of malignant tumors. SDC1 promotes the development of breast cancer by disturbing tumor stem cell phenotypes, the cell cycle and apoptosis, and then modulates macrophage migration, epithelial-mesenchymal transformation, angiogenesis and the tumor-bone microenvironment. We summarized the recent advances regarding the role of SDC1 in the mechanism driving the occurrence of breast cancer, and evaluated its potential therapeutic contributions. |
| format | Article |
| id | doaj-art-01e2b453d29d4607b4fdacb948cc7b3f |
| institution | OA Journals |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-01e2b453d29d4607b4fdacb948cc7b3f2025-08-20T01:51:30ZengBMCWorld Journal of Surgical Oncology1477-78192025-05-012311910.1186/s12957-025-03840-zSDC1 is a critical transmembrane proteoglycan in breast cancerYingying Mei0Lantao Zhao1Na Zhou2Precision Medicine Center of Oncology, The Affiliated Hospital of Qingdao University, Qingdao UniversityDepartment of Anesthesiology, The Affiliated Hospital of Qingdao UniversityPrecision Medicine Center of Oncology, The Affiliated Hospital of Qingdao University, Qingdao UniversityAbstract There has been an increasing incidence of breast cancer around the world in recent years. As a burgeoning model of diagnosis and treatment, precision medicine has become a new trend in breast cancer management. Dysregulated glycometabolism is well established as a tumor feature. SDC1 is a glycometabolism-related gene and participates in the progression, metastasis, resistance and recurrence of malignant tumors. SDC1 promotes the development of breast cancer by disturbing tumor stem cell phenotypes, the cell cycle and apoptosis, and then modulates macrophage migration, epithelial-mesenchymal transformation, angiogenesis and the tumor-bone microenvironment. We summarized the recent advances regarding the role of SDC1 in the mechanism driving the occurrence of breast cancer, and evaluated its potential therapeutic contributions.https://doi.org/10.1186/s12957-025-03840-zSDC1Breast cancerTumor microenvironmentTargeted therapy |
| spellingShingle | Yingying Mei Lantao Zhao Na Zhou SDC1 is a critical transmembrane proteoglycan in breast cancer World Journal of Surgical Oncology SDC1 Breast cancer Tumor microenvironment Targeted therapy |
| title | SDC1 is a critical transmembrane proteoglycan in breast cancer |
| title_full | SDC1 is a critical transmembrane proteoglycan in breast cancer |
| title_fullStr | SDC1 is a critical transmembrane proteoglycan in breast cancer |
| title_full_unstemmed | SDC1 is a critical transmembrane proteoglycan in breast cancer |
| title_short | SDC1 is a critical transmembrane proteoglycan in breast cancer |
| title_sort | sdc1 is a critical transmembrane proteoglycan in breast cancer |
| topic | SDC1 Breast cancer Tumor microenvironment Targeted therapy |
| url | https://doi.org/10.1186/s12957-025-03840-z |
| work_keys_str_mv | AT yingyingmei sdc1isacriticaltransmembraneproteoglycaninbreastcancer AT lantaozhao sdc1isacriticaltransmembraneproteoglycaninbreastcancer AT nazhou sdc1isacriticaltransmembraneproteoglycaninbreastcancer |