Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetes
Diabetic kidney disease is traditionally regarded as a complication of chronic hyperglycaemia associated with diabetes. However, the relationship between glycaemic thresholds and the development of diabetic kidney disease is increasingly questioned. We present a case of a 69-year-old woman with prog...
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2025-07-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5378 |
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| author | Nirmay Sonar Jarvis Pennington Mishell Siles Borda Zaynah Sadiq Matthew Beasey Sathiyendram Poobalasingham |
| author_facet | Nirmay Sonar Jarvis Pennington Mishell Siles Borda Zaynah Sadiq Matthew Beasey Sathiyendram Poobalasingham |
| author_sort | Nirmay Sonar |
| collection | DOAJ |
| description | Diabetic kidney disease is traditionally regarded as a complication of chronic hyperglycaemia associated with diabetes. However, the relationship between glycaemic thresholds and the development of diabetic kidney disease is increasingly questioned. We present a case of a 69-year-old woman with progressive renal dysfunction and biopsy findings suggestive of diabetic kidney disease, despite repeatedly normal glycosylated haemoglobin (haemoglobin A1c) and without a clinical diagnosis of diabetes or pre-diabetes. This case highlights the limitations of current haemoglobin A1c thresholds and raises the question of whether diabetic kidney disease can truly develop in the absence of diabetes. Stricter glycaemic criteria may help identify at-risk patients earlier and prevent renal complications. |
| format | Article |
| id | doaj-art-01ddc0f5685840b893f7e48a4fe811b6 |
| institution | DOAJ |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-01ddc0f5685840b893f7e48a4fe811b62025-08-20T02:56:43ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-07-0110.12890/2025_0053784913Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetesNirmay Sonar0Jarvis Pennington1Mishell Siles Borda2Zaynah Sadiq3Matthew Beasey4Sathiyendram Poobalasingham5Internal Medicine, Norton Community Hospital, Norton, USALincoln Memorial University DeBusk College of Osteopathic Medicine, Harrogate, USAInternal Medicine, Norton Community Hospital, Norton, USAInternal Medicine, Norton Community Hospital, Norton, USAEndocrinology, Johnston Memorial Hospital, Abingdon, USANephrology, Bristol Regional Medical Center, Bristol, USADiabetic kidney disease is traditionally regarded as a complication of chronic hyperglycaemia associated with diabetes. However, the relationship between glycaemic thresholds and the development of diabetic kidney disease is increasingly questioned. We present a case of a 69-year-old woman with progressive renal dysfunction and biopsy findings suggestive of diabetic kidney disease, despite repeatedly normal glycosylated haemoglobin (haemoglobin A1c) and without a clinical diagnosis of diabetes or pre-diabetes. This case highlights the limitations of current haemoglobin A1c thresholds and raises the question of whether diabetic kidney disease can truly develop in the absence of diabetes. Stricter glycaemic criteria may help identify at-risk patients earlier and prevent renal complications.https://www.ejcrim.com/index.php/EJCRIM/article/view/5378ckd managementdiabetic kidney diseasediabetic nephropathydiabetes, endocrinology |
| spellingShingle | Nirmay Sonar Jarvis Pennington Mishell Siles Borda Zaynah Sadiq Matthew Beasey Sathiyendram Poobalasingham Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetes European Journal of Case Reports in Internal Medicine ckd management diabetic kidney disease diabetic nephropathy diabetes, endocrinology |
| title | Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetes |
| title_full | Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetes |
| title_fullStr | Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetes |
| title_full_unstemmed | Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetes |
| title_short | Rethinking glycemic thresholds: diabetic kidney disease in the absence of overt diabetes |
| title_sort | rethinking glycemic thresholds diabetic kidney disease in the absence of overt diabetes |
| topic | ckd management diabetic kidney disease diabetic nephropathy diabetes, endocrinology |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5378 |
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