25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways
Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/520241 |
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| author | Anna Bonanno Sebastiano Gangemi Stefania La Grutta Velia Malizia Loredana Riccobono Paolo Colombo Fabio Cibella Mirella Profita |
| author_facet | Anna Bonanno Sebastiano Gangemi Stefania La Grutta Velia Malizia Loredana Riccobono Paolo Colombo Fabio Cibella Mirella Profita |
| author_sort | Anna Bonanno |
| collection | DOAJ |
| description | Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients. We found significant lower levels of 25(OH) Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH) Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH) Vit D. In AAR 25(OH) Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH) Vit D in AR and AAR. In conclusion, low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity. |
| format | Article |
| id | doaj-art-01dc2b6713b34447ab7e2bd234786d74 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-01dc2b6713b34447ab7e2bd234786d742025-08-20T02:03:05ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/52024152024125-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the AirwaysAnna Bonanno0Sebastiano Gangemi1Stefania La Grutta2Velia Malizia3Loredana Riccobono4Paolo Colombo5Fabio Cibella6Mirella Profita7Institute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyInstitute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyInstitute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyInstitute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyInstitute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyInstitute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyInstitute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyInstitute of Biomedicine and Molecular Immunology “A. Monroy” (IBIM), National Research Council of Italy (CNR), Palermo, ItalyLow vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH) Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients. We found significant lower levels of 25(OH) Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH) Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH) Vit D. In AAR 25(OH) Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH) Vit D in AR and AAR. In conclusion, low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity.http://dx.doi.org/10.1155/2014/520241 |
| spellingShingle | Anna Bonanno Sebastiano Gangemi Stefania La Grutta Velia Malizia Loredana Riccobono Paolo Colombo Fabio Cibella Mirella Profita 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways Mediators of Inflammation |
| title | 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways |
| title_full | 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways |
| title_fullStr | 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways |
| title_full_unstemmed | 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways |
| title_short | 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways |
| title_sort | 25 hydroxyvitamin d il 31 and il 33 in children with allergic disease of the airways |
| url | http://dx.doi.org/10.1155/2014/520241 |
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