Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning
Baclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life-threatening. The authors present the case of a 17-year...
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| Format: | Article |
| Language: | English |
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Bucharest College of Physicians
2019-06-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2019/06/RMM_art-8-1.pdf |
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| author | Cristina Iolanda Vivisenco Coriolan Emil Ulmeanu |
| author_facet | Cristina Iolanda Vivisenco Coriolan Emil Ulmeanu |
| author_sort | Cristina Iolanda Vivisenco |
| collection | DOAJ |
| description | Baclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life-threatening. The authors present the case of a 17-year old teenage girl who developed deep coma, sinus bradycardia, fi rst-degree atrioventricular block, arterial hypertension and hyperglycemia after ingesting a large dose of baclofen. The patient was successfully treated with supportive measures. Early diagnosis and prompt therapeutic intervention are key-steps in the management of acute baclofen poisoning. |
| format | Article |
| id | doaj-art-01d60d55bc2043a289b718988db9366e |
| institution | DOAJ |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-01d60d55bc2043a289b718988db9366e2025-08-20T02:55:16ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732019-06-012628588https://doi.org/10.31689/rmm.2019.26.2.85Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen PoisoningCristina Iolanda Vivisenco0Coriolan Emil Ulmeanu1Department of Toxicology, „Grigore Alexandrescu” Emergency Children Hospital, Bucharest, RomaniaDepartment of Toxicology, „Grigore Alexandrescu” Emergency Children Hospital, Bucharest, RomaniaBaclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life-threatening. The authors present the case of a 17-year old teenage girl who developed deep coma, sinus bradycardia, fi rst-degree atrioventricular block, arterial hypertension and hyperglycemia after ingesting a large dose of baclofen. The patient was successfully treated with supportive measures. Early diagnosis and prompt therapeutic intervention are key-steps in the management of acute baclofen poisoning.https://medicinamoderna.ro/wp-content/uploads/2019/06/RMM_art-8-1.pdfbaclofenpoisoningoverdosebradycardiaatrioventricular blockcomahyperglycemia |
| spellingShingle | Cristina Iolanda Vivisenco Coriolan Emil Ulmeanu Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning Modern Medicine baclofen poisoning overdose bradycardia atrioventricular block coma hyperglycemia |
| title | Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning |
| title_full | Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning |
| title_fullStr | Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning |
| title_full_unstemmed | Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning |
| title_short | Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning |
| title_sort | diagnostic and therapeutic approach in a case of severe acute baclofen poisoning |
| topic | baclofen poisoning overdose bradycardia atrioventricular block coma hyperglycemia |
| url | https://medicinamoderna.ro/wp-content/uploads/2019/06/RMM_art-8-1.pdf |
| work_keys_str_mv | AT cristinaiolandavivisenco diagnosticandtherapeuticapproachinacaseofsevereacutebaclofenpoisoning AT coriolanemilulmeanu diagnosticandtherapeuticapproachinacaseofsevereacutebaclofenpoisoning |