Diagnostic and Therapeutic approach in a Case of Severe Acute Baclofen Poisoning
Baclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life-threatening. The authors present the case of a 17-year...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Bucharest College of Physicians
2019-06-01
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| Series: | Modern Medicine |
| Subjects: | |
| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2019/06/RMM_art-8-1.pdf |
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| Summary: | Baclofen is a structural analogue of gamma-aminobutyric acid with central myorelaxant effect. Ingestion of a toxic dose of baclofen induces a clinical presentation with neurological, cardiac, respiratory and metabolic expression, sometimes life-threatening. The authors present the case of a 17-year old teenage girl who developed deep coma, sinus bradycardia, fi rst-degree atrioventricular block, arterial hypertension and hyperglycemia after ingesting a large dose of baclofen. The patient was successfully treated with supportive measures. Early diagnosis and prompt therapeutic intervention are key-steps in the management of acute baclofen poisoning. |
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| ISSN: | 1223-0472 2360-2473 |