Innate Immunity to Leishmania Infection: Within Phagocytes
Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional i...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/754965 |
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| _version_ | 1849686974728765440 |
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| author | Marcela Freitas Lopes Ana Caroline Costa-da-Silva George Alexandre DosReis |
| author_facet | Marcela Freitas Lopes Ana Caroline Costa-da-Silva George Alexandre DosReis |
| author_sort | Marcela Freitas Lopes |
| collection | DOAJ |
| description | Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for monocytes and dendritic cells. This paper addresses recent experimental findings regarding the regulation of Leishmania major infection by these major phagocyte populations. In addition, the role of IL-4 on dendritic cells and monocytes is discussed. |
| format | Article |
| id | doaj-art-01d585c335ce451d989bcdcaf1750c9a |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-01d585c335ce451d989bcdcaf1750c9a2025-08-20T03:22:30ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/754965754965Innate Immunity to Leishmania Infection: Within PhagocytesMarcela Freitas Lopes0Ana Caroline Costa-da-Silva1George Alexandre DosReis2Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, BrazilCarlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, BrazilCarlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, BrazilInfection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for monocytes and dendritic cells. This paper addresses recent experimental findings regarding the regulation of Leishmania major infection by these major phagocyte populations. In addition, the role of IL-4 on dendritic cells and monocytes is discussed.http://dx.doi.org/10.1155/2014/754965 |
| spellingShingle | Marcela Freitas Lopes Ana Caroline Costa-da-Silva George Alexandre DosReis Innate Immunity to Leishmania Infection: Within Phagocytes Mediators of Inflammation |
| title | Innate Immunity to Leishmania Infection: Within Phagocytes |
| title_full | Innate Immunity to Leishmania Infection: Within Phagocytes |
| title_fullStr | Innate Immunity to Leishmania Infection: Within Phagocytes |
| title_full_unstemmed | Innate Immunity to Leishmania Infection: Within Phagocytes |
| title_short | Innate Immunity to Leishmania Infection: Within Phagocytes |
| title_sort | innate immunity to leishmania infection within phagocytes |
| url | http://dx.doi.org/10.1155/2014/754965 |
| work_keys_str_mv | AT marcelafreitaslopes innateimmunitytoleishmaniainfectionwithinphagocytes AT anacarolinecostadasilva innateimmunitytoleishmaniainfectionwithinphagocytes AT georgealexandredosreis innateimmunitytoleishmaniainfectionwithinphagocytes |