Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system
Sialic acid is a common terminal monosaccharide residue on glycan chains, and desialylation of glycoproteins is considered an important biological signal. In the liver and other cell types, asialoglycoprotein receptor 1 (ASGR1) specifically recognizes and binds to exposed galactose or N-acetylgalact...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1653452/full |
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| author | Xuan Xiao You Nie Yiping Leng |
| author_facet | Xuan Xiao You Nie Yiping Leng |
| author_sort | Xuan Xiao |
| collection | DOAJ |
| description | Sialic acid is a common terminal monosaccharide residue on glycan chains, and desialylation of glycoproteins is considered an important biological signal. In the liver and other cell types, asialoglycoprotein receptor 1 (ASGR1) specifically recognizes and binds to exposed galactose or N-acetylgalactosamine (Gal/GalNAc) residues on desialylated glycoproteins, and activates downstream signaling pathways through receptor-mediated endocytosis (RME), thereby playing important roles in various physiological and pathological processes such as immune regulation, viral infection, hepatocellular carcinoma progression, and lipid metabolism. In addition, ASGR1 is regarded as a key target for liver-specific drug delivery. This review systematically describes the molecular structure and physiological functions of ASGR1, its roles in pathological processes, and its potential functions in extrahepatic tissues. It provides essential background information for a comprehensive understanding of ASGR1 and offers novel insights into future research directions. |
| format | Article |
| id | doaj-art-01d41c15abe6416a891f2c52772bfcc9 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-01d41c15abe6416a891f2c52772bfcc92025-08-20T03:41:00ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-08-011210.3389/fmed.2025.16534521653452Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular systemXuan Xiao0You Nie1Yiping Leng2Department of Laboratory Medicine, Hengyang Medical School, The Affiliated Changsha Central Hospital, University of South China, Changsha, ChinaDepartment of Laboratory Medicine, Hengyang Medical School, The Affiliated Changsha Central Hospital, University of South China, Changsha, ChinaHengyang Medical School, The Affiliated Changsha Central Hospital, Changsha Tuberculosis Research Institute, University of South China, Changsha, ChinaSialic acid is a common terminal monosaccharide residue on glycan chains, and desialylation of glycoproteins is considered an important biological signal. In the liver and other cell types, asialoglycoprotein receptor 1 (ASGR1) specifically recognizes and binds to exposed galactose or N-acetylgalactosamine (Gal/GalNAc) residues on desialylated glycoproteins, and activates downstream signaling pathways through receptor-mediated endocytosis (RME), thereby playing important roles in various physiological and pathological processes such as immune regulation, viral infection, hepatocellular carcinoma progression, and lipid metabolism. In addition, ASGR1 is regarded as a key target for liver-specific drug delivery. This review systematically describes the molecular structure and physiological functions of ASGR1, its roles in pathological processes, and its potential functions in extrahepatic tissues. It provides essential background information for a comprehensive understanding of ASGR1 and offers novel insights into future research directions.https://www.frontiersin.org/articles/10.3389/fmed.2025.1653452/fullASGR1glycoprotein recognitionviral infectionlipid metabolismhepatocellular carcinomatargeted drug delivery |
| spellingShingle | Xuan Xiao You Nie Yiping Leng Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system Frontiers in Medicine ASGR1 glycoprotein recognition viral infection lipid metabolism hepatocellular carcinoma targeted drug delivery |
| title | Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system |
| title_full | Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system |
| title_fullStr | Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system |
| title_full_unstemmed | Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system |
| title_short | Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system |
| title_sort | asialoglycoprotein receptor 1 a multifaceted receptor in the liver and cardiovascular system |
| topic | ASGR1 glycoprotein recognition viral infection lipid metabolism hepatocellular carcinoma targeted drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1653452/full |
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