Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease
There are nearly 50 million Alzheimer’s disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden on families and society. As a neurotransmitter and neuromodulat...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2021/5533827 |
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| author | Hui-Hua Li Xiao-Yan Yao Sheng Tao Xue Sun Pan-pan Li Xi-xin Li Zhu-Li Liu Chao Ren |
| author_facet | Hui-Hua Li Xiao-Yan Yao Sheng Tao Xue Sun Pan-pan Li Xi-xin Li Zhu-Li Liu Chao Ren |
| author_sort | Hui-Hua Li |
| collection | DOAJ |
| description | There are nearly 50 million Alzheimer’s disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden on families and society. As a neurotransmitter and neuromodulator, serotonin is involved in the regulation of psychoemotional, sleep, and feeding functions. Accumulating data support the importance of serotonin in the occurrence and development of BPSD. Studies have shown that reduction of serotonin receptors can increase depression and mental symptoms in AD patients. At present, there is no drug treatment for AD approved by the US Food and Drug Administration. Among them, agomelatine, as a new type of antidepressant, can act on serotonin 2 receptors to improve symptoms such as depression and anxiety. At present, research on BPSD is still in the preliminary exploratory stage, and there are still a lot of unknowns. This review summarizes the relationship between serotonin 2 receptors, agomelatine, and BPSD. It provides a new idea for the study of the pathogenesis and treatment of BPSD. |
| format | Article |
| id | doaj-art-01d3971065f04ee890c325e2baa865cb |
| institution | OA Journals |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-01d3971065f04ee890c325e2baa865cb2025-08-20T02:03:05ZengWileyBehavioural Neurology0953-41801875-85842021-01-01202110.1155/2021/55338275533827Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s DiseaseHui-Hua Li0Xiao-Yan Yao1Sheng Tao2Xue Sun3Pan-pan Li4Xi-xin Li5Zhu-Li Liu6Chao Ren7Zhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang 212000, Jiangsu Province, ChinaDepartment of Neurology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong Province, ChinaZhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang 212000, Jiangsu Province, ChinaZhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang 212000, Jiangsu Province, ChinaZhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang 212000, Jiangsu Province, ChinaZhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang 212000, Jiangsu Province, ChinaDepartment of Neurology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong Province, ChinaDepartment of Neurology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong Province, ChinaThere are nearly 50 million Alzheimer’s disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden on families and society. As a neurotransmitter and neuromodulator, serotonin is involved in the regulation of psychoemotional, sleep, and feeding functions. Accumulating data support the importance of serotonin in the occurrence and development of BPSD. Studies have shown that reduction of serotonin receptors can increase depression and mental symptoms in AD patients. At present, there is no drug treatment for AD approved by the US Food and Drug Administration. Among them, agomelatine, as a new type of antidepressant, can act on serotonin 2 receptors to improve symptoms such as depression and anxiety. At present, research on BPSD is still in the preliminary exploratory stage, and there are still a lot of unknowns. This review summarizes the relationship between serotonin 2 receptors, agomelatine, and BPSD. It provides a new idea for the study of the pathogenesis and treatment of BPSD.http://dx.doi.org/10.1155/2021/5533827 |
| spellingShingle | Hui-Hua Li Xiao-Yan Yao Sheng Tao Xue Sun Pan-pan Li Xi-xin Li Zhu-Li Liu Chao Ren Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease Behavioural Neurology |
| title | Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease |
| title_full | Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease |
| title_fullStr | Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease |
| title_full_unstemmed | Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease |
| title_short | Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease |
| title_sort | serotonin 2 receptors agomelatine and behavioral and psychological symptoms of dementia in alzheimer s disease |
| url | http://dx.doi.org/10.1155/2021/5533827 |
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