Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases
We report on the clinical course and histopathologic muscle alterations of five patients diagnosed with neurosarcoidosis, who underwent biopsy due to their muscle manifestations. The five patients were females and only one was less than 40 years of age. Proximal muscle weakness was presented by all...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
2001-06-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000300007&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850245614908997632 |
|---|---|
| author | Rosana Herminia Scola Lineu Cesar Werneck Daniel Monte Serrat Prevedello Priscila Greboge Fábio Massaiti Iwamoto |
| author_facet | Rosana Herminia Scola Lineu Cesar Werneck Daniel Monte Serrat Prevedello Priscila Greboge Fábio Massaiti Iwamoto |
| author_sort | Rosana Herminia Scola |
| collection | DOAJ |
| description | We report on the clinical course and histopathologic muscle alterations of five patients diagnosed with neurosarcoidosis, who underwent biopsy due to their muscle manifestations. The five patients were females and only one was less than 40 years of age. Proximal muscle weakness was presented by all and only two patients complained of myalgia. Only normal values of serum muscle enzymes were detected. Electromyography revealed diverse findings such as normal, myopathic and neuropathic patterns. Granuloma was not present in one muscle biopsy. Two patients thoroughly recovered by taking only prednisone and one patient required a methotrexate addition for 3 months before becoming asymptomatic. The other two patients received azathioprine, one due to steroid side effects but without a satisfactory evolution, and the other to strengthen the prednisone régime, with excellent results. |
| format | Article |
| id | doaj-art-01d28460ceea4e61a659f7c8a181239a |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2001-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-01d28460ceea4e61a659f7c8a181239a2025-08-20T01:59:26ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272001-06-01592B34735210.1590/S0004-282X2001000300007Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 casesRosana Herminia Scola0Lineu Cesar Werneck1Daniel Monte Serrat Prevedello2Priscila Greboge3Fábio Massaiti Iwamoto4Universidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáWe report on the clinical course and histopathologic muscle alterations of five patients diagnosed with neurosarcoidosis, who underwent biopsy due to their muscle manifestations. The five patients were females and only one was less than 40 years of age. Proximal muscle weakness was presented by all and only two patients complained of myalgia. Only normal values of serum muscle enzymes were detected. Electromyography revealed diverse findings such as normal, myopathic and neuropathic patterns. Granuloma was not present in one muscle biopsy. Two patients thoroughly recovered by taking only prednisone and one patient required a methotrexate addition for 3 months before becoming asymptomatic. The other two patients received azathioprine, one due to steroid side effects but without a satisfactory evolution, and the other to strengthen the prednisone régime, with excellent results.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000300007&tlng=ensarcoidosismyositisgranulomacentral nervous system diseases |
| spellingShingle | Rosana Herminia Scola Lineu Cesar Werneck Daniel Monte Serrat Prevedello Priscila Greboge Fábio Massaiti Iwamoto Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases Arquivos de Neuro-Psiquiatria sarcoidosis myositis granuloma central nervous system diseases |
| title | Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases |
| title_full | Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases |
| title_fullStr | Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases |
| title_full_unstemmed | Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases |
| title_short | Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases |
| title_sort | symptomatic muscle involvement in neurosarcoidosis a clinicopathological study of 5 cases |
| topic | sarcoidosis myositis granuloma central nervous system diseases |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000300007&tlng=en |
| work_keys_str_mv | AT rosanaherminiascola symptomaticmuscleinvolvementinneurosarcoidosisaclinicopathologicalstudyof5cases AT lineucesarwerneck symptomaticmuscleinvolvementinneurosarcoidosisaclinicopathologicalstudyof5cases AT danielmonteserratprevedello symptomaticmuscleinvolvementinneurosarcoidosisaclinicopathologicalstudyof5cases AT priscilagreboge symptomaticmuscleinvolvementinneurosarcoidosisaclinicopathologicalstudyof5cases AT fabiomassaitiiwamoto symptomaticmuscleinvolvementinneurosarcoidosisaclinicopathologicalstudyof5cases |