Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials
Introduction: Organ preservation (OP) strategies are gaining interest in improving the quality of life in the management of rectal cancer, particularly for tumors located in the distal or middle rectum. The optimal OP protocol is still not standardized and relies on randomized trials. This review su...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Oncologica |
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| Online Access: | https://medicaljournalssweden.se/actaoncologica/article/view/41057 |
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| author | Syrine Ben Dhia Damien Chauviere Diana Mitrea Renaud Schiappa Tanguy Pace Loscos Emmanuel Chamorey David Baron |
| author_facet | Syrine Ben Dhia Damien Chauviere Diana Mitrea Renaud Schiappa Tanguy Pace Loscos Emmanuel Chamorey David Baron |
| author_sort | Syrine Ben Dhia |
| collection | DOAJ |
| description | Introduction: Organ preservation (OP) strategies are gaining interest in improving the quality of life in the management of rectal cancer, particularly for tumors located in the distal or middle rectum. The optimal OP protocol is still not standardized and relies on randomized trials. This review summarizes past and ongoing studies on OP protocols for adenocarcinoma of the distal and middle rectum.
Method: We searched for articles and abstracts on randomized clinical trials investigating OP approaches for rectal cancer, including data presented at the LUCARRE Congress held in Nice on November 25, 2023, covering ongoing and recently published trials on rectal preservation.
Results: Our review’s findings are presented in four tables: the first evaluates key trials with overall survival (OS) as the primary endpoint; the second provides an overview of past Phase III trials; the third reviews Phase II/III trials that specifically focus on local excisions (LE); and finally, the fourth summarizes ongoing trials. Each table is accompanied by detailed comments elucidating the significance and implications of the presented data, alongside a review of current guidelines.
Interpretation: We highlight the growing interest in OP strategies for rectal cancer management to enhance patients’ quality of life. Despite the lack of international consensus on the optimal OP protocol, past and ongoing randomized trials provide valuable findings into the evolving management strategies of rectal cancer treatment. The presented data supports the role of randomized phase III trials to provide evidence for a change in clinical practice.
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| format | Article |
| id | doaj-art-01c9515a8ce64ea7822c6a97680f1fb7 |
| institution | Kabale University |
| issn | 1651-226X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Oncologica |
| spelling | doaj-art-01c9515a8ce64ea7822c6a97680f1fb72025-01-28T06:50:20ZengMedical Journals SwedenActa Oncologica1651-226X2025-01-016410.2340/1651-226X.2025.41057Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trialsSyrine Ben Dhia0Damien Chauviere1Diana Mitrea2Renaud Schiappa3Tanguy Pace Loscos 4Emmanuel Chamorey 5David Baron6Department of Radiotherapy, Antoine Lacassagne Center, Nice, FranceDepartment of Clinical Research and Innovation, Antoine Lacassagne Center, Nice, FranceDepartment of Radiotherapy, Antoine Lacassagne Center, Nice, FranceDepartment of Epidemiology, Biostatistics and Health Data, Centre Antoine Lacassagne, University of Côte d'Azur, Nice, FranceDepartment of Epidemiology, Biostatistics and Health Data, Centre Antoine Lacassagne, University of Côte d'Azur, Nice, FranceDepartment of Epidemiology, Biostatistics and Health Data, Centre Antoine Lacassagne, University of Côte d'Azur, Nice, FranceDepartment of Radiotherapy, Antoine Lacassagne Center, Nice, FranceIntroduction: Organ preservation (OP) strategies are gaining interest in improving the quality of life in the management of rectal cancer, particularly for tumors located in the distal or middle rectum. The optimal OP protocol is still not standardized and relies on randomized trials. This review summarizes past and ongoing studies on OP protocols for adenocarcinoma of the distal and middle rectum. Method: We searched for articles and abstracts on randomized clinical trials investigating OP approaches for rectal cancer, including data presented at the LUCARRE Congress held in Nice on November 25, 2023, covering ongoing and recently published trials on rectal preservation. Results: Our review’s findings are presented in four tables: the first evaluates key trials with overall survival (OS) as the primary endpoint; the second provides an overview of past Phase III trials; the third reviews Phase II/III trials that specifically focus on local excisions (LE); and finally, the fourth summarizes ongoing trials. Each table is accompanied by detailed comments elucidating the significance and implications of the presented data, alongside a review of current guidelines. Interpretation: We highlight the growing interest in OP strategies for rectal cancer management to enhance patients’ quality of life. Despite the lack of international consensus on the optimal OP protocol, past and ongoing randomized trials provide valuable findings into the evolving management strategies of rectal cancer treatment. The presented data supports the role of randomized phase III trials to provide evidence for a change in clinical practice. https://medicaljournalssweden.se/actaoncologica/article/view/41057Rectal cancerorgan preservationcontact x-ray therapy |
| spellingShingle | Syrine Ben Dhia Damien Chauviere Diana Mitrea Renaud Schiappa Tanguy Pace Loscos Emmanuel Chamorey David Baron Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials Acta Oncologica Rectal cancer organ preservation contact x-ray therapy |
| title | Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials |
| title_full | Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials |
| title_fullStr | Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials |
| title_full_unstemmed | Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials |
| title_short | Organ preservation, for rectal cancer: general overview of the latest data from phase III randomized trials |
| title_sort | organ preservation for rectal cancer general overview of the latest data from phase iii randomized trials |
| topic | Rectal cancer organ preservation contact x-ray therapy |
| url | https://medicaljournalssweden.se/actaoncologica/article/view/41057 |
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