Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer
Background: Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities. Aims: To study the expression and correlation of P53 protein and epithelial–mesenchymal transition (EMT) related makers in NSCLC...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_277_24 |
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| _version_ | 1849243569444880384 |
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| author | Xiangmei Wu Lijiang Duan |
| author_facet | Xiangmei Wu Lijiang Duan |
| author_sort | Xiangmei Wu |
| collection | DOAJ |
| description | Background:
Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities.
Aims:
To study the expression and correlation of P53 protein and epithelial–mesenchymal transition (EMT) related makers in NSCLC.
Materials and Methods:
32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers.
Results:
The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis (P < 0.05). A positive association was found between P53 and EMT (r = 0.380, P < 0.05).
Conclusions:
There is a positive association between P53, snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis. |
| format | Article |
| id | doaj-art-01c5e69c75324f7dbf724ea3ed80b922 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-01c5e69c75324f7dbf724ea3ed80b9222025-08-20T03:59:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-04-0168230030410.4103/ijpm.ijpm_277_24Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancerXiangmei WuLijiang DuanBackground: Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities. Aims: To study the expression and correlation of P53 protein and epithelial–mesenchymal transition (EMT) related makers in NSCLC. Materials and Methods: 32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers. Results: The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis (P < 0.05). A positive association was found between P53 and EMT (r = 0.380, P < 0.05). Conclusions: There is a positive association between P53, snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis.https://journals.lww.com/10.4103/ijpm.ijpm_277_24epithelial–mesenchymal transitionimmunohistochemistrynon-small cell lung cancerp53 |
| spellingShingle | Xiangmei Wu Lijiang Duan Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer Indian Journal of Pathology and Microbiology epithelial–mesenchymal transition immunohistochemistry non-small cell lung cancer p53 |
| title | Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer |
| title_full | Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer |
| title_fullStr | Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer |
| title_full_unstemmed | Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer |
| title_short | Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer |
| title_sort | correlation of p53 expression and epithelial mesenchymal transition in non small cell lung cancer |
| topic | epithelial–mesenchymal transition immunohistochemistry non-small cell lung cancer p53 |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_277_24 |
| work_keys_str_mv | AT xiangmeiwu correlationofp53expressionandepithelialmesenchymaltransitioninnonsmallcelllungcancer AT lijiangduan correlationofp53expressionandepithelialmesenchymaltransitioninnonsmallcelllungcancer |