Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer
Background: Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities. Aims: To study the expression and correlation of P53 protein and epithelial–mesenchymal transition (EMT) related makers in NSCLC...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_277_24 |
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| Summary: | Background:
Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities.
Aims:
To study the expression and correlation of P53 protein and epithelial–mesenchymal transition (EMT) related makers in NSCLC.
Materials and Methods:
32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers.
Results:
The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis (P < 0.05). A positive association was found between P53 and EMT (r = 0.380, P < 0.05).
Conclusions:
There is a positive association between P53, snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis. |
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| ISSN: | 0377-4929 0974-5130 |