Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review
<b>Background</b>: Diffusion tensor imaging (DTI), a variant of Diffusion Weighted Imaging (DWI), enables a neuroanatomical microscopic-like examination of the brain, which can detect brain damage using physical parameters. DTI’s application to traumatic brain injury (TBI) has the potent...
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2025-01-01
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| Online Access: | https://www.mdpi.com/2076-3425/15/1/70 |
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| author | Federica Paolini Salvatore Marrone Gianluca Scalia Rosa Maria Gerardi Lapo Bonosi Umberto Emanuele Benigno Sofia Musso Alba Scerrati Domenico Gerardo Iacopino Francesco Signorelli Rosario Maugeri Massimiliano Visocchi |
| author_facet | Federica Paolini Salvatore Marrone Gianluca Scalia Rosa Maria Gerardi Lapo Bonosi Umberto Emanuele Benigno Sofia Musso Alba Scerrati Domenico Gerardo Iacopino Francesco Signorelli Rosario Maugeri Massimiliano Visocchi |
| author_sort | Federica Paolini |
| collection | DOAJ |
| description | <b>Background</b>: Diffusion tensor imaging (DTI), a variant of Diffusion Weighted Imaging (DWI), enables a neuroanatomical microscopic-like examination of the brain, which can detect brain damage using physical parameters. DTI’s application to traumatic brain injury (TBI) has the potential to reveal radiological features that can assist in predicting the clinical outcomes of these patients. What is the ongoing role of DTI in detecting brain alterations and predicting neurological outcomes in patients with moderate to severe traumatic brain injury and/or diffuse axonal injury? <b>Methods</b>: A scoping review of the PubMed, Scopus, EMBASE, and Cochrane databases was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The aim was to identify all potentially relevant studies concerning the role of DTI in TBI. From an initial pool of 3527 publications, 26 articles were selected based on relevance. These studies included a total of 729 patients with moderate to severe TBI and/or diffuse axonal injury. DTI parameters were analyzed to determine their relationship with neurological outcomes post-TBI, with assessments of several brain functions and regions. <b>Results</b>: The studies included various DTI parameters, identifying significant relationships between DTI variations and neurological outcomes following TBI. Multiple brain functions and regions were evaluated, demonstrating the capability of DTI to detect brain alterations with higher accuracy, sensitivity, and specificity than MRI alone. <b>Conclusions</b>: DTI is a valuable tool for detecting brain alterations in TBI patients, offering enhanced accuracy, sensitivity, and specificity compared to MRI alone. Recent studies confirm its effectiveness in identifying neurological impairments and predicting outcomes in patients following brain trauma, underscoring its utility in clinical settings for managing TBI. |
| format | Article |
| id | doaj-art-01c597ab5cd34a98976e3ea4c88b22b8 |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-01c597ab5cd34a98976e3ea4c88b22b82025-01-24T13:25:52ZengMDPI AGBrain Sciences2076-34252025-01-011517010.3390/brainsci15010070Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping ReviewFederica Paolini0Salvatore Marrone1Gianluca Scalia2Rosa Maria Gerardi3Lapo Bonosi4Umberto Emanuele Benigno5Sofia Musso6Alba Scerrati7Domenico Gerardo Iacopino8Francesco Signorelli9Rosario Maugeri10Massimiliano Visocchi11Neurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyUnit of Neurosurgery, Sant’Elia Hospital, 93100 Caltanissetta, ItalyNeurosurgery Unit, Department of Head and Neck Surgery, ARNAS Garibaldi, 95124 Catania, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyFondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyNeurosurgical Clinic, AOUP “Paolo Giaccone”, Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyCVJ Operative Unit, CVJ Research Center Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy<b>Background</b>: Diffusion tensor imaging (DTI), a variant of Diffusion Weighted Imaging (DWI), enables a neuroanatomical microscopic-like examination of the brain, which can detect brain damage using physical parameters. DTI’s application to traumatic brain injury (TBI) has the potential to reveal radiological features that can assist in predicting the clinical outcomes of these patients. What is the ongoing role of DTI in detecting brain alterations and predicting neurological outcomes in patients with moderate to severe traumatic brain injury and/or diffuse axonal injury? <b>Methods</b>: A scoping review of the PubMed, Scopus, EMBASE, and Cochrane databases was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The aim was to identify all potentially relevant studies concerning the role of DTI in TBI. From an initial pool of 3527 publications, 26 articles were selected based on relevance. These studies included a total of 729 patients with moderate to severe TBI and/or diffuse axonal injury. DTI parameters were analyzed to determine their relationship with neurological outcomes post-TBI, with assessments of several brain functions and regions. <b>Results</b>: The studies included various DTI parameters, identifying significant relationships between DTI variations and neurological outcomes following TBI. Multiple brain functions and regions were evaluated, demonstrating the capability of DTI to detect brain alterations with higher accuracy, sensitivity, and specificity than MRI alone. <b>Conclusions</b>: DTI is a valuable tool for detecting brain alterations in TBI patients, offering enhanced accuracy, sensitivity, and specificity compared to MRI alone. Recent studies confirm its effectiveness in identifying neurological impairments and predicting outcomes in patients following brain trauma, underscoring its utility in clinical settings for managing TBI.https://www.mdpi.com/2076-3425/15/1/70traumatic brain injury (TBI)diffuse axonal injury (DAI)diffusion tensor imaging (DTI)white matter (WM) |
| spellingShingle | Federica Paolini Salvatore Marrone Gianluca Scalia Rosa Maria Gerardi Lapo Bonosi Umberto Emanuele Benigno Sofia Musso Alba Scerrati Domenico Gerardo Iacopino Francesco Signorelli Rosario Maugeri Massimiliano Visocchi Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review Brain Sciences traumatic brain injury (TBI) diffuse axonal injury (DAI) diffusion tensor imaging (DTI) white matter (WM) |
| title | Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review |
| title_full | Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review |
| title_fullStr | Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review |
| title_full_unstemmed | Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review |
| title_short | Diffusion Tensor Imaging as Neurologic Predictor in Patients Affected by Traumatic Brain Injury: Scoping Review |
| title_sort | diffusion tensor imaging as neurologic predictor in patients affected by traumatic brain injury scoping review |
| topic | traumatic brain injury (TBI) diffuse axonal injury (DAI) diffusion tensor imaging (DTI) white matter (WM) |
| url | https://www.mdpi.com/2076-3425/15/1/70 |
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