Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation

Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation

Abstract Background The Rho GTPase Rac family small GTPase 1 (RAC1) is considered a promising fibrotic therapeutic target, but the role of its activator, dedicator of cytokinesis 2 (DOCK2), in liver fibrosis is largely unknown. This study aimed to investigate the expression and role of DOCK2 in chol...

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Bibliographic Details
Main Authors: Jianli Qiu, Yitong Qu, Yinli Li, Cancan Li, Junling Wang, Lu Meng, Xiaojin Jing, Jiangping Fu, Yan Xu, Yuna Chai
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Biology Direct
Subjects:
DOCK2
RAC1
Cholestasis
Liver fibrosis
Hepatic stellate cell
Macrophage polarisation
Online Access:https://doi.org/10.1186/s13062-025-00612-3
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