Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis

Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis

Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and further distant metastasis. Previous studies have documented the important roles of gut microbiota-host interactions in...

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Bibliographic Details
Main Authors: Ying Zhang, Lu Zhang, Sheng Zheng, Mengjie Li, Chaochao Xu, Dingjiacheng Jia, Yadong Qi, Tongyao Hou, Lan Wang, Boya Wang, Aiqing Li, Shujie Chen, Jianmin Si, Wei Zhuo
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Gut microbes
adhesion
ICAM1
ALPK1
colorectal cancer metastasis
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2038852
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