Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety
Abstract Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptual...
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55008-0 |
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| author | Zhiyi Chen Yancheng Tang Xuerong Liu Wei Li Yuanyuan Hu Bowen Hu Ting Xu Rong Zhang Lei Xia Jing-Xuan Zhang Zhibing Xiao Ji Chen Zhengzhi Feng Yuan Zhou Qinghua He Jiang Qiu Xu Lei Hong Chen Shaozheng Qin Tingyong Feng |
| author_facet | Zhiyi Chen Yancheng Tang Xuerong Liu Wei Li Yuanyuan Hu Bowen Hu Ting Xu Rong Zhang Lei Xia Jing-Xuan Zhang Zhibing Xiao Ji Chen Zhengzhi Feng Yuan Zhou Qinghua He Jiang Qiu Xu Lei Hong Chen Shaozheng Qin Tingyong Feng |
| author_sort | Zhiyi Chen |
| collection | DOAJ |
| description | Abstract Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these patterns were moderately heritable, and identified their genetic connectome-transcriptional markers that were associated with the neurobiological enrichment of vasculature and cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed a general factor of bridging symptoms and its neurobiological architectures, which enriched neurogenetic understanding of depression-anxiety comorbidity. |
| format | Article |
| id | doaj-art-01ba762141f54fae84bee22d1b2a1182 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-01ba762141f54fae84bee22d1b2a11822025-01-19T12:29:40ZengNature PortfolioNature Communications2041-17232024-12-0115111510.1038/s41467-024-55008-0Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxietyZhiyi Chen0Yancheng Tang1Xuerong Liu2Wei Li3Yuanyuan Hu4Bowen Hu5Ting Xu6Rong Zhang7Lei Xia8Jing-Xuan Zhang9Zhibing Xiao10Ji Chen11Zhengzhi Feng12Yuan Zhou13Qinghua He14Jiang Qiu15Xu Lei16Hong Chen17Shaozheng Qin18Tingyong Feng19Experimental Research Center for Medical and Psychological Science, School of Psychology, Third Military Medical UniversityKey Laboratory of Brain-Machine Intelligence for Information Behavior (Ministry of Education and Shanghai), School of Business and Management, Shanghai International Studies UniversityExperimental Research Center for Medical and Psychological Science, School of Psychology, Third Military Medical UniversityExperimental Research Center for Medical and Psychological Science, School of Psychology, Third Military Medical UniversityCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of SciencesState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversitySchool of Psychology, Southwest UniversitySchool of Psychology, Southwest UniversityExperimental Research Center for Medical and Psychological Science, School of Psychology, Third Military Medical UniversityExperimental Research Center for Medical and Psychological Science, School of Psychology, Third Military Medical UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversityCenter for Brain Health and Brain Technology, Global Institute of Future Technology, Institute of Psychology and Behavioral Science, Shanghai Jiao Tong UniversityExperimental Research Center for Medical and Psychological Science, School of Psychology, Third Military Medical UniversityCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of SciencesSchool of Psychology, Southwest UniversitySchool of Psychology, Southwest UniversitySchool of Psychology, Southwest UniversitySchool of Psychology, Southwest UniversityState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal UniversitySchool of Psychology, Southwest UniversityAbstract Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these patterns were moderately heritable, and identified their genetic connectome-transcriptional markers that were associated with the neurobiological enrichment of vasculature and cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed a general factor of bridging symptoms and its neurobiological architectures, which enriched neurogenetic understanding of depression-anxiety comorbidity.https://doi.org/10.1038/s41467-024-55008-0 |
| spellingShingle | Zhiyi Chen Yancheng Tang Xuerong Liu Wei Li Yuanyuan Hu Bowen Hu Ting Xu Rong Zhang Lei Xia Jing-Xuan Zhang Zhibing Xiao Ji Chen Zhengzhi Feng Yuan Zhou Qinghua He Jiang Qiu Xu Lei Hong Chen Shaozheng Qin Tingyong Feng Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety Nature Communications |
| title | Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety |
| title_full | Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety |
| title_fullStr | Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety |
| title_full_unstemmed | Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety |
| title_short | Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety |
| title_sort | edge centric connectome genetic markers of bridging factor to comorbidity between depression and anxiety |
| url | https://doi.org/10.1038/s41467-024-55008-0 |
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