Virological Mechanisms in the Coinfection between HIV and HCV
Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the cou...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/320532 |
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| _version_ | 1832567560432779264 |
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| author | Maria Carla Liberto Emilia Zicca Grazia Pavia Angela Quirino Nadia Marascio Carlo Torti Alfredo Focà |
| author_facet | Maria Carla Liberto Emilia Zicca Grazia Pavia Angela Quirino Nadia Marascio Carlo Torti Alfredo Focà |
| author_sort | Maria Carla Liberto |
| collection | DOAJ |
| description | Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the course of HCV infection, increasing the risk of cirrhosis and hepatocellular carcinoma. Also, HCV might increase immunological defects due to HIV and risk of comorbidities. A specific cross-talk among HIV and HCV proteins in coinfected patients modulates the natural history, the immune responses, and the life cycle of both viruses. These effects are mediated by immune mechanisms and by a cross-talk between the two viruses which could interfere with host defense mechanisms. In this review, we focus on some virological/immunological mechanisms of the pathogenetic interactions between HIV and HCV in the human host. |
| format | Article |
| id | doaj-art-01b376dfa65a47eea19de281eb225f8a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-01b376dfa65a47eea19de281eb225f8a2025-02-03T01:01:01ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/320532320532Virological Mechanisms in the Coinfection between HIV and HCVMaria Carla Liberto0Emilia Zicca1Grazia Pavia2Angela Quirino3Nadia Marascio4Carlo Torti5Alfredo Focà6Department of Health Sciences, Institute of Microbiology, School of Medicine, University of “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University of “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University of “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University of “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University of “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, School of Medicine, University of “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University of “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDue to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the course of HCV infection, increasing the risk of cirrhosis and hepatocellular carcinoma. Also, HCV might increase immunological defects due to HIV and risk of comorbidities. A specific cross-talk among HIV and HCV proteins in coinfected patients modulates the natural history, the immune responses, and the life cycle of both viruses. These effects are mediated by immune mechanisms and by a cross-talk between the two viruses which could interfere with host defense mechanisms. In this review, we focus on some virological/immunological mechanisms of the pathogenetic interactions between HIV and HCV in the human host.http://dx.doi.org/10.1155/2015/320532 |
| spellingShingle | Maria Carla Liberto Emilia Zicca Grazia Pavia Angela Quirino Nadia Marascio Carlo Torti Alfredo Focà Virological Mechanisms in the Coinfection between HIV and HCV Mediators of Inflammation |
| title | Virological Mechanisms in the Coinfection between HIV and HCV |
| title_full | Virological Mechanisms in the Coinfection between HIV and HCV |
| title_fullStr | Virological Mechanisms in the Coinfection between HIV and HCV |
| title_full_unstemmed | Virological Mechanisms in the Coinfection between HIV and HCV |
| title_short | Virological Mechanisms in the Coinfection between HIV and HCV |
| title_sort | virological mechanisms in the coinfection between hiv and hcv |
| url | http://dx.doi.org/10.1155/2015/320532 |
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