PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES
Allotransplantation of pancreatic islets remains the most effective method of treatment of diabetes mellitus type 1 being capable under combination of favorable conditions (suffi cient number of isolated islets, effective combination of immunosuppressive drugs) to reach the recipients’ insulin indep...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2017-01-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/708 |
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| author | G. N. Skaletskaya N. N. Skaletskiy V. I. Sevastianov |
| author_facet | G. N. Skaletskaya N. N. Skaletskiy V. I. Sevastianov |
| author_sort | G. N. Skaletskaya |
| collection | DOAJ |
| description | Allotransplantation of pancreatic islets remains the most effective method of treatment of diabetes mellitus type 1 being capable under combination of favorable conditions (suffi cient number of isolated islets, effective combination of immunosuppressive drugs) to reach the recipients’ insulin independence for several years. However, the overwhelming shortage of donor pancreas and limited post-transplantation islet survival do not allow increasing the number of such transplants and their effectiveness. This review presents a critical analysis of the work done by Russian and foreign authors onto creation of tissue-engineered pancreatic constructs that may lead to the resolution of the three main pancreatic islet transplantation issues: 1) lack of donor material; 2) necessity of immunosuppressive therapy; 3) limited survival and functional activity of the islet. |
| format | Article |
| id | doaj-art-01b2e6912ece426e822275e8b505952d |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2017-01-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-01b2e6912ece426e822275e8b505952d2025-08-20T03:01:39ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912017-01-0118413314510.15825/1995-1191-2016-4-133-145592PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETESG. N. Skaletskaya0N. N. Skaletskiy1V. I. Sevastianov2V.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationV.I. Shumakov Federal Research Center of Transplantology and Artifi cial Organs of the Ministry of Healthcare of the Russian FederationAllotransplantation of pancreatic islets remains the most effective method of treatment of diabetes mellitus type 1 being capable under combination of favorable conditions (suffi cient number of isolated islets, effective combination of immunosuppressive drugs) to reach the recipients’ insulin independence for several years. However, the overwhelming shortage of donor pancreas and limited post-transplantation islet survival do not allow increasing the number of such transplants and their effectiveness. This review presents a critical analysis of the work done by Russian and foreign authors onto creation of tissue-engineered pancreatic constructs that may lead to the resolution of the three main pancreatic islet transplantation issues: 1) lack of donor material; 2) necessity of immunosuppressive therapy; 3) limited survival and functional activity of the islet.https://journal.transpl.ru/vtio/article/view/708diabetes mellitus type 1transplantationisletspancreastissue-engineered constructs |
| spellingShingle | G. N. Skaletskaya N. N. Skaletskiy V. I. Sevastianov PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES Вестник трансплантологии и искусственных органов diabetes mellitus type 1 transplantation islets pancreas tissue-engineered constructs |
| title | PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES |
| title_full | PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES |
| title_fullStr | PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES |
| title_full_unstemmed | PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES |
| title_short | PROSPECTS OF APPLICATION OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS IN THE TREATMENT OF TYPE 1 DIABETES |
| title_sort | prospects of application of tissue engineered pancreatic constructs in the treatment of type 1 diabetes |
| topic | diabetes mellitus type 1 transplantation islets pancreas tissue-engineered constructs |
| url | https://journal.transpl.ru/vtio/article/view/708 |
| work_keys_str_mv | AT gnskaletskaya prospectsofapplicationoftissueengineeredpancreaticconstructsinthetreatmentoftype1diabetes AT nnskaletskiy prospectsofapplicationoftissueengineeredpancreaticconstructsinthetreatmentoftype1diabetes AT visevastianov prospectsofapplicationoftissueengineeredpancreaticconstructsinthetreatmentoftype1diabetes |