Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair
Abstract Abdominal Aortic Aneurysm (AAA) poses a significant health risk due to its silent nature and high mortality upon rupture. The Fib-4 index, initially designed for liver fibrosis assessment, presents potential beyond its scope. This study aims to investigate the association of FIB-4 with aneu...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88133-x |
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| author | Mohamad Jamalinia Seyed Alireza Mirhosseini Maryam Ranjbar Kamran Bagheri Lankarani Ahmad Hosseinzadeh |
| author_facet | Mohamad Jamalinia Seyed Alireza Mirhosseini Maryam Ranjbar Kamran Bagheri Lankarani Ahmad Hosseinzadeh |
| author_sort | Mohamad Jamalinia |
| collection | DOAJ |
| description | Abstract Abdominal Aortic Aneurysm (AAA) poses a significant health risk due to its silent nature and high mortality upon rupture. The Fib-4 index, initially designed for liver fibrosis assessment, presents potential beyond its scope. This study aims to investigate the association of FIB-4 with aneurysm size and mortality risk, exploring its utility as a risk predictor for enhanced clinical management. This retrospective longitudinal research studied 141 AAA open repair surgery patients (92% male, mean age of 70 years (SD: 11.5)) from October 2016 to September 2021 for a median follow-up 35 months (IQR: 0.7 – 56.6). All-cause mortality was the primary outcome. Adjusted hazard ratios (aHR) were calculated for each Fib-4 cut-off between 1.5 and 3.25. FIB-4 cut-off range of 2.58–2.74 was associated with higher mortality risk in adjusted HR. Specifically, FIB-4 ≥ 2.67 increased mortality by 78% (aHR:1.78, 95% CI: 1.06 – 3.00). Furthermore, FIB-4 ≥ 2.67 was significantly associated with a baseline aneurysm size ≥ 8cm (aOR: 2.67, 95% CI: 1.17 – 6.09). FIB-4 was independently associated with a higher mortality risk and higher aneurysm size. These findings suggest that FIB-4 assessment in clinical practice may enhance risk profiling, aiding in more precise stratification and management strategies for AAA patients. |
| format | Article |
| id | doaj-art-01b2806d0a3847be90a20191aff8afb6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-01b2806d0a3847be90a20191aff8afb62025-02-02T12:22:32ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-88133-xAssociation of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repairMohamad Jamalinia0Seyed Alireza Mirhosseini1Maryam Ranjbar2Kamran Bagheri Lankarani3Ahmad Hosseinzadeh4Gastroenterohepatology Research Center, Shiraz University of Medical SciencesCardiovascular Research Center, School of Medicine, Shiraz University of Medical SciencesGastroenterohepatology Research Center, Shiraz University of Medical SciencesHealth Policy Research Center, Institute of Health, Shiraz University of Medical SciencesThoracic and Vascular Surgery Research Center, Namazi Hospital, Shiraz University of Medical SciencesAbstract Abdominal Aortic Aneurysm (AAA) poses a significant health risk due to its silent nature and high mortality upon rupture. The Fib-4 index, initially designed for liver fibrosis assessment, presents potential beyond its scope. This study aims to investigate the association of FIB-4 with aneurysm size and mortality risk, exploring its utility as a risk predictor for enhanced clinical management. This retrospective longitudinal research studied 141 AAA open repair surgery patients (92% male, mean age of 70 years (SD: 11.5)) from October 2016 to September 2021 for a median follow-up 35 months (IQR: 0.7 – 56.6). All-cause mortality was the primary outcome. Adjusted hazard ratios (aHR) were calculated for each Fib-4 cut-off between 1.5 and 3.25. FIB-4 cut-off range of 2.58–2.74 was associated with higher mortality risk in adjusted HR. Specifically, FIB-4 ≥ 2.67 increased mortality by 78% (aHR:1.78, 95% CI: 1.06 – 3.00). Furthermore, FIB-4 ≥ 2.67 was significantly associated with a baseline aneurysm size ≥ 8cm (aOR: 2.67, 95% CI: 1.17 – 6.09). FIB-4 was independently associated with a higher mortality risk and higher aneurysm size. These findings suggest that FIB-4 assessment in clinical practice may enhance risk profiling, aiding in more precise stratification and management strategies for AAA patients.https://doi.org/10.1038/s41598-025-88133-xLiver fibrosisAbdominal aortic aneurysmCardiovascular diseaseRisk stratification |
| spellingShingle | Mohamad Jamalinia Seyed Alireza Mirhosseini Maryam Ranjbar Kamran Bagheri Lankarani Ahmad Hosseinzadeh Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair Scientific Reports Liver fibrosis Abdominal aortic aneurysm Cardiovascular disease Risk stratification |
| title | Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair |
| title_full | Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair |
| title_fullStr | Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair |
| title_full_unstemmed | Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair |
| title_short | Association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair |
| title_sort | association of liver fibrosis with aneurysm size and mortality risk in patients undergoing open abdominal aortic aneurysm repair |
| topic | Liver fibrosis Abdominal aortic aneurysm Cardiovascular disease Risk stratification |
| url | https://doi.org/10.1038/s41598-025-88133-x |
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