Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy
Purpose: To evaluate vascular changes on optical coherence tomography angiography (OCTA) in patients with diabetic macular ischemia (DMI) after systemic normobaric oxygen (NBO) therapy. Methods: This before–after interventional study included 26 eyes of 26 patients with DMI. Macular OCTA was perfo...
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Knowledge E
2025-05-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| author | Diba Idani Seyed Mohammadjavad Mashhadi Hamze Babaei Farideh Sharifipour Ramin Nourinia Bahareh Kheiri Arezoo Miraftabi |
| author_facet | Diba Idani Seyed Mohammadjavad Mashhadi Hamze Babaei Farideh Sharifipour Ramin Nourinia Bahareh Kheiri Arezoo Miraftabi |
| author_sort | Diba Idani |
| collection | DOAJ |
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Purpose: To evaluate vascular changes on optical coherence tomography angiography (OCTA) in patients with diabetic macular ischemia (DMI) after systemic normobaric oxygen (NBO) therapy.
Methods: This before–after interventional study included 26 eyes of 26 patients with DMI. Macular OCTA was performed before and after 1 hour of 100% NBO therapy at a flow of 10 L/min delivered by face mask. As primary outcomes, changes in OCTA metrics were evaluated using the paired t-test. Subgroup analyses were performed based on gender. The secondary outcomes included identifying parameters correlated with best-corrected visual acuity (BCVA) and factors associated with improvement in OCTA parameters.
Results: The patients included 15 males and 11 females aged 59.48 ± 9.67 years. Overall, no significant change was observed in retinal thickness; however, there was a significant decrease in retinal thickness among females and a significant increase among males (P < 0.001). The foveal avascular zone (FAZ) decreased significantly from 0.38 ± 0.14 to 0.34 ± 0.12 mm2 (P = 0.035). Superficial capillary plexus vessel density (SCP-VD) and deep capillary plexus vessel density (DCP-VD) at fovea increased from 13.5 ± 6.37 to 14.98 ± 6.33% (P = 0.059) and from 24.61 ± 6.75 to 26.59 ± 6.16% (P = 0.022), respectively. In males, BCVA correlated significantly with baseline DCP parameters but corresponded with none of the SCP parameters. In females, BCVA significantly correlated with pre-O2 DCP-VD of the perifoveal inferior quadrant. Finally, regression analysis did not show any parameter that could predict a favorable response.
Conclusion: Using OCTA, we observed a decrease in FAZ and an increase in DCP-VD at fovea after short-term NBO therapy for patients with DMI.
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| format | Article |
| id | doaj-art-01afe6cf4b584678bd2b127b5fd166b5 |
| institution | DOAJ |
| issn | 2008-2010 2008-322X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Knowledge E |
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| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj-art-01afe6cf4b584678bd2b127b5fd166b52025-08-20T03:22:19ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2025-05-012010.18502/jovr.v20.15354Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen TherapyDiba Idani0https://orcid.org/0000-0001-7406-9869Seyed Mohammadjavad Mashhadi1https://orcid.org/0009-0003-3763-3506Hamze Babaei2https://orcid.org/0009-0006-5829-2407Farideh Sharifipour3https://orcid.org/0000-0002-1511-9608Ramin Nourinia4https://orcid.org/0000-0002-2630-1069Bahareh Kheiri5https://orcid.org/0000-0001-9448-8104Arezoo Miraftabi6School of Medicine, Shahid Beheshti University of Medical Sciences, TehranOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, TehranOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, TehranOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, TehranOphthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, TehranDepartment of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, OntarioEye Research Center, Five Senses Health Institute, Moheb Kowsar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran Purpose: To evaluate vascular changes on optical coherence tomography angiography (OCTA) in patients with diabetic macular ischemia (DMI) after systemic normobaric oxygen (NBO) therapy. Methods: This before–after interventional study included 26 eyes of 26 patients with DMI. Macular OCTA was performed before and after 1 hour of 100% NBO therapy at a flow of 10 L/min delivered by face mask. As primary outcomes, changes in OCTA metrics were evaluated using the paired t-test. Subgroup analyses were performed based on gender. The secondary outcomes included identifying parameters correlated with best-corrected visual acuity (BCVA) and factors associated with improvement in OCTA parameters. Results: The patients included 15 males and 11 females aged 59.48 ± 9.67 years. Overall, no significant change was observed in retinal thickness; however, there was a significant decrease in retinal thickness among females and a significant increase among males (P < 0.001). The foveal avascular zone (FAZ) decreased significantly from 0.38 ± 0.14 to 0.34 ± 0.12 mm2 (P = 0.035). Superficial capillary plexus vessel density (SCP-VD) and deep capillary plexus vessel density (DCP-VD) at fovea increased from 13.5 ± 6.37 to 14.98 ± 6.33% (P = 0.059) and from 24.61 ± 6.75 to 26.59 ± 6.16% (P = 0.022), respectively. In males, BCVA correlated significantly with baseline DCP parameters but corresponded with none of the SCP parameters. In females, BCVA significantly correlated with pre-O2 DCP-VD of the perifoveal inferior quadrant. Finally, regression analysis did not show any parameter that could predict a favorable response. Conclusion: Using OCTA, we observed a decrease in FAZ and an increase in DCP-VD at fovea after short-term NBO therapy for patients with DMI. https://knepublishing.com/index.php/JOVR/article/view/15354Diabetic Macular IschemiaFoveal Avascular ZoneOptical Coherence Tomography AngiographyOxygen Therapy |
| spellingShingle | Diba Idani Seyed Mohammadjavad Mashhadi Hamze Babaei Farideh Sharifipour Ramin Nourinia Bahareh Kheiri Arezoo Miraftabi Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy Journal of Ophthalmic & Vision Research Diabetic Macular Ischemia Foveal Avascular Zone Optical Coherence Tomography Angiography Oxygen Therapy |
| title | Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy |
| title_full | Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy |
| title_fullStr | Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy |
| title_full_unstemmed | Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy |
| title_short | Optical Coherence Tomography Angiography Changes in Diabetic Macular Ischemia after Systemic Normobaric Oxygen Therapy |
| title_sort | optical coherence tomography angiography changes in diabetic macular ischemia after systemic normobaric oxygen therapy |
| topic | Diabetic Macular Ischemia Foveal Avascular Zone Optical Coherence Tomography Angiography Oxygen Therapy |
| url | https://knepublishing.com/index.php/JOVR/article/view/15354 |
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