Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome

Abstract Drug addiction is one of the most important global problems. Medicinal herbs have been traditionally used in the management and treatment of opioid withdrawal syndrome and pain. The aim of this study was to determine the effect of A. dracunculus essential oil in reducing the symptoms of mor...

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Main Authors: Zahra Lorigooini, Fatemeh Heibati, Seyyed Matin Ahmadi, Sareh Mohammadi, Mahmoud Rafieian-Kopaei
Format: Article
Language:English
Published: Universidade de São Paulo 2025-01-01
Series:Brazilian Journal of Pharmaceutical Sciences
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Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100302&lng=en&tlng=en
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author Zahra Lorigooini
Fatemeh Heibati
Seyyed Matin Ahmadi
Sareh Mohammadi
Mahmoud Rafieian-Kopaei
author_facet Zahra Lorigooini
Fatemeh Heibati
Seyyed Matin Ahmadi
Sareh Mohammadi
Mahmoud Rafieian-Kopaei
author_sort Zahra Lorigooini
collection DOAJ
description Abstract Drug addiction is one of the most important global problems. Medicinal herbs have been traditionally used in the management and treatment of opioid withdrawal syndrome and pain. The aim of this study was to determine the effect of A. dracunculus essential oil in reducing the symptoms of morphine withdrawal in mice. Male mice (25-30 g) were randomly assigned into 4 groups (n=10). Morphine-dependent groups received morphine (50 and 75 mg/kg ip; three times/day, 3 days) and a single injection of morphine (50 mg/kg) and then naloxone on the fourth day via IP injection. The control group received saline. The post-treated group received morphine for 3 days; on the fourth day, ten minutes before receiving naloxone, A. dracunculus essential oil with a dose of 75 mg/kg was injected. All groups received naloxone 2 hours after receiving the last dose of morphine; then, the morphine withdrawal symptoms were measured for 30 minutes. In the post-treated and co-treated groups, the body stretching and shaking the claw were significantly less than morphine-dependent groups (p<0/05). Also, in the post-treated and co-treated groups, the blinking, itching, and the number of standing on two legs significantly decreased compared to the morphine group. Hence, it might be concluded that A. dracunculus essential oil can significantly reduce morphine withdrawal symptoms.
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spelling doaj-art-01afb41a6efc47a5b66f68b9808636b92025-01-21T07:41:17ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902025-01-016110.1590/s2175-97902025e20131Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndromeZahra LorigooiniFatemeh HeibatiSeyyed Matin AhmadiSareh MohammadiMahmoud Rafieian-Kopaeihttps://orcid.org/0000-0003-3190-7863Abstract Drug addiction is one of the most important global problems. Medicinal herbs have been traditionally used in the management and treatment of opioid withdrawal syndrome and pain. The aim of this study was to determine the effect of A. dracunculus essential oil in reducing the symptoms of morphine withdrawal in mice. Male mice (25-30 g) were randomly assigned into 4 groups (n=10). Morphine-dependent groups received morphine (50 and 75 mg/kg ip; three times/day, 3 days) and a single injection of morphine (50 mg/kg) and then naloxone on the fourth day via IP injection. The control group received saline. The post-treated group received morphine for 3 days; on the fourth day, ten minutes before receiving naloxone, A. dracunculus essential oil with a dose of 75 mg/kg was injected. All groups received naloxone 2 hours after receiving the last dose of morphine; then, the morphine withdrawal symptoms were measured for 30 minutes. In the post-treated and co-treated groups, the body stretching and shaking the claw were significantly less than morphine-dependent groups (p<0/05). Also, in the post-treated and co-treated groups, the blinking, itching, and the number of standing on two legs significantly decreased compared to the morphine group. Hence, it might be concluded that A. dracunculus essential oil can significantly reduce morphine withdrawal symptoms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100302&lng=en&tlng=enMiceArtemisia dracunculusMorphineEssential oil
spellingShingle Zahra Lorigooini
Fatemeh Heibati
Seyyed Matin Ahmadi
Sareh Mohammadi
Mahmoud Rafieian-Kopaei
Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome
Brazilian Journal of Pharmaceutical Sciences
Mice
Artemisia dracunculus
Morphine
Essential oil
title Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome
title_full Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome
title_fullStr Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome
title_full_unstemmed Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome
title_short Artemisia dracunculus essential oil: phytochemical study, pre-treatment and co-treatment effects on morphine withdrawal syndrome
title_sort artemisia dracunculus essential oil phytochemical study pre treatment and co treatment effects on morphine withdrawal syndrome
topic Mice
Artemisia dracunculus
Morphine
Essential oil
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100302&lng=en&tlng=en
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