Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections

Background: Surgical site infections (SSIs) are a serious concern in cesarean sections, leading to research on improved preventive measures, to evaluate the effectiveness of standard antibiotic prophylaxis alone versus an extended regimen that includes azithromycin in reducing SSIs in nonelective ce...

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Main Authors: Sumangali Thirunavukkarausu, Poornima Chinnappa, Anupriya Kaliamoorthi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
Online Access:https://journals.lww.com/10.4103/jpbs.jpbs_783_24
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author Sumangali Thirunavukkarausu
Poornima Chinnappa
Anupriya Kaliamoorthi
author_facet Sumangali Thirunavukkarausu
Poornima Chinnappa
Anupriya Kaliamoorthi
author_sort Sumangali Thirunavukkarausu
collection DOAJ
description Background: Surgical site infections (SSIs) are a serious concern in cesarean sections, leading to research on improved preventive measures, to evaluate the effectiveness of standard antibiotic prophylaxis alone versus an extended regimen that includes azithromycin in reducing SSIs in nonelective cesarean sections. Methods: In this randomized controlled trial, 288 women who were undergoing nonelective cesarean sections at a tertiary care hospital in South India were involved. Participants were divided into two groups: one receiving standard prophylaxis with cefazolin and the other receiving an extended regimen with azithromycin. The main focus was on the occurrence of SSIs within six weeks after the surgery. Results: The extended regimen group had a slightly lower incidence of SSIs (1.42%) compared to the standard regimen group (6.12%), but this difference did not reach statistical significance (P = 0.112). Conclusion: Although the inclusion of azithromycin alongside standard prophylactic antibiotics demonstrated a slight decrease in SSIs, the results did not reach statistical significance. These findings indicate potential advantages in certain patient groups, which should be explored in more detail.
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institution Kabale University
issn 0976-4879
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publishDate 2024-12-01
publisher Wolters Kluwer Medknow Publications
record_format Article
series Journal of Pharmacy and Bioallied Sciences
spelling doaj-art-01ad2458a16b4058ba32c1d734679ff02025-01-12T14:23:24ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3370S337310.4103/jpbs.jpbs_783_24Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean SectionsSumangali ThirunavukkarausuPoornima ChinnappaAnupriya KaliamoorthiBackground: Surgical site infections (SSIs) are a serious concern in cesarean sections, leading to research on improved preventive measures, to evaluate the effectiveness of standard antibiotic prophylaxis alone versus an extended regimen that includes azithromycin in reducing SSIs in nonelective cesarean sections. Methods: In this randomized controlled trial, 288 women who were undergoing nonelective cesarean sections at a tertiary care hospital in South India were involved. Participants were divided into two groups: one receiving standard prophylaxis with cefazolin and the other receiving an extended regimen with azithromycin. The main focus was on the occurrence of SSIs within six weeks after the surgery. Results: The extended regimen group had a slightly lower incidence of SSIs (1.42%) compared to the standard regimen group (6.12%), but this difference did not reach statistical significance (P = 0.112). Conclusion: Although the inclusion of azithromycin alongside standard prophylactic antibiotics demonstrated a slight decrease in SSIs, the results did not reach statistical significance. These findings indicate potential advantages in certain patient groups, which should be explored in more detail.https://journals.lww.com/10.4103/jpbs.jpbs_783_24antibiotic prophylaxisazithromycincesarean sectionnonelective cesareansurgical site infections
spellingShingle Sumangali Thirunavukkarausu
Poornima Chinnappa
Anupriya Kaliamoorthi
Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections
Journal of Pharmacy and Bioallied Sciences
antibiotic prophylaxis
azithromycin
cesarean section
nonelective cesarean
surgical site infections
title Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections
title_full Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections
title_fullStr Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections
title_full_unstemmed Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections
title_short Efficacy of Extended Antibiotic Prophylaxis with Azithromycin in Cesarean Sections
title_sort efficacy of extended antibiotic prophylaxis with azithromycin in cesarean sections
topic antibiotic prophylaxis
azithromycin
cesarean section
nonelective cesarean
surgical site infections
url https://journals.lww.com/10.4103/jpbs.jpbs_783_24
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AT poornimachinnappa efficacyofextendedantibioticprophylaxiswithazithromycinincesareansections
AT anupriyakaliamoorthi efficacyofextendedantibioticprophylaxiswithazithromycinincesareansections