Measurement of tepotinib by UPLC‒MS/MS and its interaction with naringenin in rats

Measurement of tepotinib by UPLC‒MS/MS and its interaction with naringenin in rats

Abstract We established a method based on ultra performance liquid chromatography tandem mass spectrometry (UPLC‒MS/MS) to quantitatively measure tepotinib, which was validated as acceptable and used in the evaluation of food-drug interactions between tepotinib and naringenin in rats. We used pemiga...

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Bibliographic Details
Main Authors: Zhe Chen, Chaojie Chen, Ya-nan Liu, Xinhao Xu, Shunbin Luo
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Chemistry
Subjects:
Tepotinib
Pharmacokinetics
Naringenin
Drug‒drug interaction
UPLC‒MS/MS
Online Access:https://doi.org/10.1186/s13065-024-01293-1
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