Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain
Background: Acute post-thoracotomy pain (APTP) is severe and can lead to various respiratory complications if left untreated. Epidural (Ep) analgesia is the gold standard for APTP relief. Aims and Objectives: The aims and objectives of this study were to study the impact of low-dose oral pregabal...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2025-05-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ajmsjournal.info/index.php/AJMS/article/view/4484 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850196491140857856 |
|---|---|
| author | Swati Dogra Altaf Hussain Mir Suhail Sidiq Rohey Jan Talib Khan Syed Amer Zahoor Hakeem Zubair Ashraf Shaqul Qamar Wani Sandeep Verma Guddi Devi Mohammad Syed Taha |
| author_facet | Swati Dogra Altaf Hussain Mir Suhail Sidiq Rohey Jan Talib Khan Syed Amer Zahoor Hakeem Zubair Ashraf Shaqul Qamar Wani Sandeep Verma Guddi Devi Mohammad Syed Taha |
| author_sort | Swati Dogra |
| collection | DOAJ |
| description | Background: Acute post-thoracotomy pain (APTP) is severe and can lead to various respiratory complications if left untreated. Epidural (Ep) analgesia is the gold standard for APTP relief.
Aims and Objectives: The aims and objectives of this study were to study the impact of low-dose oral pregabalin 75 mg on APTP.
Materials and Methods: 100 patients were randomized into two groups (Group P and C). The Group P, study group received pregabalin 75 mg per oral preoperatively and for 2 days postoperatively. Group C received no medication. All the patients received thoracic Ep as a standard practice. Postoperatively Visual Analog Scale (VAS), modified Ramsay sedation scoring (RSS), number of Ep top-ups, and adverse effects were noted.
Results: The age and gender of the patients in both the groups were comparable. No statistically significant difference was found between Group P versus Group C with regard to VAS score, RSS, number of Ep top-ups, and any adverse effects. VAS between the groups at 4 h, 36 h, and 48 h postoperatively were statistically significant differences (P<0.05). VAS score at 48 h was not statistically significant (P>0.05). Ep analgesia was sufficient in both the groups and no patient in either group required intravenous fentanyl as rescue analgesia. No adverse effects were reported in any groups (P>0.05).
Conclusion: Oral Pregabalin 75 mg did not reduce the severity of acute postoperative pain after thoracotomy. Study with higher doses of pregabalin needs to be carried out to evaluate the benefits of pregabalin on APTP. |
| format | Article |
| id | doaj-art-01aa58872741427c8c2c03e022e0a005 |
| institution | OA Journals |
| issn | 2467-9100 2091-0576 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj-art-01aa58872741427c8c2c03e022e0a0052025-08-20T02:13:27ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762025-05-011655965https://doi.org/10.71152/ajms.v16i5.4484Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy painSwati Dogra 0https://orcid.org/0009-0005-2932-3748Altaf Hussain Mir 1https://orcid.org/0009-0003-8684-1854Suhail Sidiq 2https://orcid.org/0000-0003-3544-0148Rohey Jan3https://orcid.org/0009-0001-0481-5800Talib Khan 4https://orcid.org/0000-0002-2211-5701Syed Amer Zahoor 5https://orcid.org/0009-0003-9618-0279Hakeem Zubair Ashraf 6https://orcid.org/0000-0002-8803-2925Shaqul Qamar Wani 7https://orcid.org/0000-0001-9530-467XSandeep Verma 8https://orcid.org/0009-0008-9399-8979Guddi Devi 9https://orcid.org/0009-0007-0056-880XMohammad Syed Taha 10https://orcid.org/0009-0006-3115-395XAssistant Professor, Department of Anesthesiology, Maharishi Markandeshwar University, Solan, Himachal Pradesh, India Assistant Professor, Division of Cardiovascular and Thoracic Anaesthesiology and Cardio-Thoracic Surgical Intensive Care, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Associate Professor, Department of Critical Care Medicine, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Assistant Professor, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Professor (Additional), Division of Cardiovascular and Thoracic Anaesthesiology and Cardio-Thoracic Surgical Intensive Care, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Professor and Head, Department of Anesthesiology, Hamdard Institute of Medical Sciences and Research, New Delhi, India Associate Professor and Head, Department of Cardiovascular and Thoracic Surgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Professor (Additional) and Head Pain and Palliative Care Unit, Department of Radiation Oncology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Assistant Professor, Department of Orthopedics, Maharishi Markandeshwar University, Solan, Himachal Pradesh, India Registrar, Department of Anesthesiology, Government Medical College, Doda, Jammu and Kashmir, India Postgraduate Resident, Department of Anesthesiology, Robert Packer Hospital, Pennsylvania, USA Background: Acute post-thoracotomy pain (APTP) is severe and can lead to various respiratory complications if left untreated. Epidural (Ep) analgesia is the gold standard for APTP relief. Aims and Objectives: The aims and objectives of this study were to study the impact of low-dose oral pregabalin 75 mg on APTP. Materials and Methods: 100 patients were randomized into two groups (Group P and C). The Group P, study group received pregabalin 75 mg per oral preoperatively and for 2 days postoperatively. Group C received no medication. All the patients received thoracic Ep as a standard practice. Postoperatively Visual Analog Scale (VAS), modified Ramsay sedation scoring (RSS), number of Ep top-ups, and adverse effects were noted. Results: The age and gender of the patients in both the groups were comparable. No statistically significant difference was found between Group P versus Group C with regard to VAS score, RSS, number of Ep top-ups, and any adverse effects. VAS between the groups at 4 h, 36 h, and 48 h postoperatively were statistically significant differences (P<0.05). VAS score at 48 h was not statistically significant (P>0.05). Ep analgesia was sufficient in both the groups and no patient in either group required intravenous fentanyl as rescue analgesia. No adverse effects were reported in any groups (P>0.05). Conclusion: Oral Pregabalin 75 mg did not reduce the severity of acute postoperative pain after thoracotomy. Study with higher doses of pregabalin needs to be carried out to evaluate the benefits of pregabalin on APTP.https://ajmsjournal.info/index.php/AJMS/article/view/4484post-thoracotomy pain; pregabalin; epidural analgesia; visual analogue scale; ramsay sedation scoring |
| spellingShingle | Swati Dogra Altaf Hussain Mir Suhail Sidiq Rohey Jan Talib Khan Syed Amer Zahoor Hakeem Zubair Ashraf Shaqul Qamar Wani Sandeep Verma Guddi Devi Mohammad Syed Taha Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain Asian Journal of Medical Sciences post-thoracotomy pain; pregabalin; epidural analgesia; visual analogue scale; ramsay sedation scoring |
| title | Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain |
| title_full | Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain |
| title_fullStr | Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain |
| title_full_unstemmed | Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain |
| title_short | Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain |
| title_sort | low dose oral pregabalin is not effective enough to control the acute post thoracotomy pain |
| topic | post-thoracotomy pain; pregabalin; epidural analgesia; visual analogue scale; ramsay sedation scoring |
| url | https://ajmsjournal.info/index.php/AJMS/article/view/4484 |
| work_keys_str_mv | AT swatidogra lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT altafhussainmir lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT suhailsidiq lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT roheyjan lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT talibkhan lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT syedamerzahoor lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT hakeemzubairashraf lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT shaqulqamarwani lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT sandeepverma lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT guddidevi lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain AT mohammadsyedtaha lowdoseoralpregabalinisnoteffectiveenoughtocontroltheacutepostthoracotomypain |