Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid Korean
Background The positive relationship between triiodothyronine (T3) and steatotic liver disease (SLD) demonstrated only in crosssectional study. We aimed to evaluated whether total T3 (TT3) is associated with the development/resolution of SLD in longitudinal design. Methods This retrospective, longit...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Endocrine Society
2025-02-01
|
| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/upload/pdf/enm-2024-2040.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850262599657062400 |
|---|---|
| author | Hye In Kim Jun Young Kim Jung Hwan Cho Ji Min Han Sunghwan Suh Ji Cheol Bae Tae Hyuk Kim Sun Wook Kim Jong Ryeal Hahm Jae Hoon Chung |
| author_facet | Hye In Kim Jun Young Kim Jung Hwan Cho Ji Min Han Sunghwan Suh Ji Cheol Bae Tae Hyuk Kim Sun Wook Kim Jong Ryeal Hahm Jae Hoon Chung |
| author_sort | Hye In Kim |
| collection | DOAJ |
| description | Background The positive relationship between triiodothyronine (T3) and steatotic liver disease (SLD) demonstrated only in crosssectional study. We aimed to evaluated whether total T3 (TT3) is associated with the development/resolution of SLD in longitudinal design. Methods This retrospective, longitudinal, population-based cohort study included 1,665 South Korean euthyroid adults with ≥4 thyroid function test. We explored the impact of mean TT3 during follow-up on development/resolution of either SLD (diagnosed by ultrasound) or modified metabolic dysfunction-associated steatotic liver disease (MASLD) using Cox proportional hazards regression models. Results During about median 5 years follow-up, 807/1,216 (66.3%) participants among participants without SLD at baseline developed SLD, and 253/318 (79.5%) participants among participants with SLD at baseline SLD resolved fatty liver. Mean TT3 rather than thyroid stimulating hormone or mean free thyroxine was significantly related with development (adjusted hazard ratio [HR], 1.01; 95% confidence interval [CI], 1.00 to 1.02; P=0.002) and resolution (adjusted HR, 0.97; 95% CI, 0.96 to 0.99; P=0.005) of SLD. Compared with low mean TT3 group, high mean TT3 group was positively associated with development of SLD (adjusted HR, 1.20; 95% CI, 1.05 to 1.38; P=0.008) and inversely associated with resolution of SLD (adjusted HR, 0.66; 95% CI, 0.51 to 0.85; P=0.001). The statistical significance remained for development (adjusted HR, 1.29; 95% CI, 1.10 to 1.51; P=0.001) and resolution (adjusted HR, 0.71; 95% CI, 0.54 to 0.94; P=0.018) of modified MASLD. Conclusion In Korean euthyroid adults, TT3 level was associated with development and resolution of either SLD or modified MASLD. |
| format | Article |
| id | doaj-art-01a6c386749f46e8bd40eacd2e3892b6 |
| institution | OA Journals |
| issn | 2093-596X 2093-5978 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj-art-01a6c386749f46e8bd40eacd2e3892b62025-08-20T01:55:09ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782025-02-0140113514510.3803/EnM.2024.20402561Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid KoreanHye In Kim0Jun Young Kim1Jung Hwan Cho2Ji Min Han3Sunghwan Suh4Ji Cheol Bae5Tae Hyuk Kim6Sun Wook Kim7Jong Ryeal Hahm8Jae Hoon Chung9 Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea Division of Gastroenterology, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground The positive relationship between triiodothyronine (T3) and steatotic liver disease (SLD) demonstrated only in crosssectional study. We aimed to evaluated whether total T3 (TT3) is associated with the development/resolution of SLD in longitudinal design. Methods This retrospective, longitudinal, population-based cohort study included 1,665 South Korean euthyroid adults with ≥4 thyroid function test. We explored the impact of mean TT3 during follow-up on development/resolution of either SLD (diagnosed by ultrasound) or modified metabolic dysfunction-associated steatotic liver disease (MASLD) using Cox proportional hazards regression models. Results During about median 5 years follow-up, 807/1,216 (66.3%) participants among participants without SLD at baseline developed SLD, and 253/318 (79.5%) participants among participants with SLD at baseline SLD resolved fatty liver. Mean TT3 rather than thyroid stimulating hormone or mean free thyroxine was significantly related with development (adjusted hazard ratio [HR], 1.01; 95% confidence interval [CI], 1.00 to 1.02; P=0.002) and resolution (adjusted HR, 0.97; 95% CI, 0.96 to 0.99; P=0.005) of SLD. Compared with low mean TT3 group, high mean TT3 group was positively associated with development of SLD (adjusted HR, 1.20; 95% CI, 1.05 to 1.38; P=0.008) and inversely associated with resolution of SLD (adjusted HR, 0.66; 95% CI, 0.51 to 0.85; P=0.001). The statistical significance remained for development (adjusted HR, 1.29; 95% CI, 1.10 to 1.51; P=0.001) and resolution (adjusted HR, 0.71; 95% CI, 0.54 to 0.94; P=0.018) of modified MASLD. Conclusion In Korean euthyroid adults, TT3 level was associated with development and resolution of either SLD or modified MASLD.http://e-enm.org/upload/pdf/enm-2024-2040.pdfthyroid hormonestriiodothyroninefatty liverlongitudinal studies |
| spellingShingle | Hye In Kim Jun Young Kim Jung Hwan Cho Ji Min Han Sunghwan Suh Ji Cheol Bae Tae Hyuk Kim Sun Wook Kim Jong Ryeal Hahm Jae Hoon Chung Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid Korean Endocrinology and Metabolism thyroid hormones triiodothyronine fatty liver longitudinal studies |
| title | Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid Korean |
| title_full | Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid Korean |
| title_fullStr | Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid Korean |
| title_full_unstemmed | Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid Korean |
| title_short | Triiodothyronine Is Associated with Incidence/Resolution of Steatotic Liver Disease: Longitudinal Study in Euthyroid Korean |
| title_sort | triiodothyronine is associated with incidence resolution of steatotic liver disease longitudinal study in euthyroid korean |
| topic | thyroid hormones triiodothyronine fatty liver longitudinal studies |
| url | http://e-enm.org/upload/pdf/enm-2024-2040.pdf |
| work_keys_str_mv | AT hyeinkim triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT junyoungkim triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT junghwancho triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT jiminhan triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT sunghwansuh triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT jicheolbae triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT taehyukkim triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT sunwookkim triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT jongryealhahm triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean AT jaehoonchung triiodothyronineisassociatedwithincidenceresolutionofsteatoticliverdiseaselongitudinalstudyineuthyroidkorean |