Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study
Objectives This study aimed to assess the prevalence of treatment-resistant depression (TRD) and associated factors among patients with major depressive disorder (MDD) on follow-up at Amanuel Mental Specialised Hospital, Addis Ababa, Ethiopia, 2021.Design and setting An institution-based cross-secti...
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BMJ Publishing Group
2024-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/11/e087006.full |
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| author | Tolesa Fanta Jerman Dereje Merga Siyoum Esayas Kibrom Eyerusalem Matheyose Kemeriya Adem Deribe Bekele Henock Asfaw Samuel Demissie Darcho |
| author_facet | Tolesa Fanta Jerman Dereje Merga Siyoum Esayas Kibrom Eyerusalem Matheyose Kemeriya Adem Deribe Bekele Henock Asfaw Samuel Demissie Darcho |
| author_sort | Tolesa Fanta |
| collection | DOAJ |
| description | Objectives This study aimed to assess the prevalence of treatment-resistant depression (TRD) and associated factors among patients with major depressive disorder (MDD) on follow-up at Amanuel Mental Specialised Hospital, Addis Ababa, Ethiopia, 2021.Design and setting An institution-based cross-sectional study design was employed using systematic random sampling techniques from 17 February to 26 March 2021.Participants The study enrolled 412 participants with a response rate of 97.6%. The study population consisted of Saint Amanuel Mental Specialised Hospital follow-up patients with MDDs and all adult patients aged above 18.Main outcome measures The main outcome of this study was TRD, which was measured using the Hospital Anxiety and Depression Scale-Depression (HADS-D). The collected data were entered into Epi-data software version 3.1 and exported to the statistical package for social science version 20 for analysis. Bivariate and multivariate logistic regression analyses were used to identify associated factors with TRD. The OR with a 95% CI was used to assess the strength of the association.Results The prevalence of TRD was 41.5% (95% CI: 37.2 to 46.1). Female sex [AOR=2.43, 95% CI: 1.57 to 3.75], comorbid psychosis [AOR=1.89, 95% CI: 1.19 to 2.99], comorbid medical illness [AOR=1.67, 95% CI: 1.09 to 2.55] and family history of mental illness [AOR=2.27, 95% CI: 1.38 to 3.74] were factors significantly associated with TRD.Conclusion and recommendation In this study, the prevalence of TRD among patients with MDDs on follow-up was high. Therefore, to improve outcomes, screening for TRD and creating specific diagnostic techniques are necessary. Additionally, preventive interventions against TRD must be established. |
| format | Article |
| id | doaj-art-01a587777e4245a684041732d058bcf0 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-01a587777e4245a684041732d058bcf02025-08-20T02:50:14ZengBMJ Publishing GroupBMJ Open2044-60552024-11-01141110.1136/bmjopen-2024-087006Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional studyTolesa Fanta0Jerman Dereje1Merga Siyoum2Esayas Kibrom3Eyerusalem Matheyose4Kemeriya Adem5Deribe Bekele6Henock Asfaw7Samuel Demissie Darcho82 Research and Training Department, Saint Amanuel mental Specialized Hospital, Harar, Ethiopia6 Psychiatry, Haramaya University, College of Health and Medical Sciences, Harar, Ethiopia1 Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia2 Research and Training Department, Saint Amanuel mental Specialized Hospital, Harar, Ethiopia1 Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia1 Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia3 School of Nusing, Haramaya University, College of Health and Medical Science, Harar, Ethiopia4 Psychiatry, Haramaya University,College of Health and Medical Science, Harar, Ethiopia5 School of Public Health, Haramaya University,College of Health and Medical Science, Harar, EthiopiaObjectives This study aimed to assess the prevalence of treatment-resistant depression (TRD) and associated factors among patients with major depressive disorder (MDD) on follow-up at Amanuel Mental Specialised Hospital, Addis Ababa, Ethiopia, 2021.Design and setting An institution-based cross-sectional study design was employed using systematic random sampling techniques from 17 February to 26 March 2021.Participants The study enrolled 412 participants with a response rate of 97.6%. The study population consisted of Saint Amanuel Mental Specialised Hospital follow-up patients with MDDs and all adult patients aged above 18.Main outcome measures The main outcome of this study was TRD, which was measured using the Hospital Anxiety and Depression Scale-Depression (HADS-D). The collected data were entered into Epi-data software version 3.1 and exported to the statistical package for social science version 20 for analysis. Bivariate and multivariate logistic regression analyses were used to identify associated factors with TRD. The OR with a 95% CI was used to assess the strength of the association.Results The prevalence of TRD was 41.5% (95% CI: 37.2 to 46.1). Female sex [AOR=2.43, 95% CI: 1.57 to 3.75], comorbid psychosis [AOR=1.89, 95% CI: 1.19 to 2.99], comorbid medical illness [AOR=1.67, 95% CI: 1.09 to 2.55] and family history of mental illness [AOR=2.27, 95% CI: 1.38 to 3.74] were factors significantly associated with TRD.Conclusion and recommendation In this study, the prevalence of TRD among patients with MDDs on follow-up was high. Therefore, to improve outcomes, screening for TRD and creating specific diagnostic techniques are necessary. Additionally, preventive interventions against TRD must be established.https://bmjopen.bmj.com/content/14/11/e087006.full |
| spellingShingle | Tolesa Fanta Jerman Dereje Merga Siyoum Esayas Kibrom Eyerusalem Matheyose Kemeriya Adem Deribe Bekele Henock Asfaw Samuel Demissie Darcho Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study BMJ Open |
| title | Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study |
| title_full | Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study |
| title_fullStr | Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study |
| title_full_unstemmed | Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study |
| title_short | Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study |
| title_sort | prevalence of treatment resistant depression and associated factors among major depressive disorder follow up patients at saint amanuel mental specialised hospital in ethiopia a cross sectional study |
| url | https://bmjopen.bmj.com/content/14/11/e087006.full |
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